摘要
作者自1989～1991年间,设计具有特异性的个体骨转移瘤化疗药物筛选并应用于肿瘤浸润淋巴细胞的过继免疫治疗临床。测试药物为长春新碱、阿霉索、顺铂、氨甲喋呤、氟脲嘧啶、丝裂霉素等6种,计138次敏感性试验,实验总有效敏感率为31.88%,临床按mg/m^2/W 常规剂量用药,有效率为47.83%(P<0.01)。
In this study,it was discribed 138 times short term drug rapid chemosensitivity screening testingof individual bone metastatic tumor in vitro,and clinical chemotherapy outcome of 23 cases bonemetastatic tumor on basis of antineoplastic sensitiveness during adoptive immunotherapy,AIT withtumor infiltrating lymphocytes,TIL from 1989～1991.The different drug was Vineristini Sulfas,A-driamycine,Cisplatih,Methotrexatum,5—Fluorouracil and Mitomycin C Kyowa.The result showedthat the drug sensitivity effective rate was 31.88 percent in laboratory,and 47.83 percent in clinic(P<0.01).It emphasized that bone metastatic tumor with TIL immunotherapy would be used bychemotherapy of rational,safety,less toxicity and efficient.
出处
《苏州医学院学报》
1992年第3期206-208,257,共3页
Acta Academiae Medicinae Suzhou
基金
江苏省卫生厅资助课题
关键词
骨肿瘤
肿瘤转移
免疫疗法
bone metastatic tumor
antineoplastic drug
TIL immunotherapy
