摘要
目的 :探讨Fc受体γ链基因 3′端非翻译区 (3′ -UTR) 380 4位点T/G多态现象在中国南方汉族人群中的分布及与系统性红斑狼疮 (SLE)的关系。方法 :采用PCR -RFLP方法分析Fc受体γ链基因 3′ -UTR 380 4位点T/G单碱基替换的多态现象。结果 :在 16 8例SLE患者和 12 0例正常人中只发现 1例SLE患者存在该位点的T/G杂合现象 ,该杂合现象经基因测序证实 ,其余均位TT型。结论 :Fc受体γ链基因 3′ -UTR 380 4位点T/G单碱基替换的多态性现象在中国南方汉族人群中少见 ,该位点的基因多态现象与SLE发病无关。
Objective:To investigate the T/G polymorphism at position 3 804 in 3′untranslated region(3′-UTR) of Fc receptor γ chain gene in populations of the Han nationality in southern China and the correlation with systemic lupus erythematosis(SLE).Methods:The T/G all genotype was determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP)method.Results:Out of 120 normal controls and 168 patients with SLE, only one SLE patient with T/G genotype was detected and the others were found with T/T genotype. This T/G heterozygosis was confirmed by sequencing.Conclusion:The T/G polymorphism at position 3804 in 3′-UTR of Fc receptor gene is rare in populations of southern China and this polymorphism has no relationship with SLE.
出处
《中国中西医结合肾病杂志》
2003年第12期688-690,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
广东省中山大学"2 11"工程基金资助项目 (No .9815 1)
广东省中医药管理局基金资助项目 (No .10 0 110 )
