摘要
目的 :观察鼓室内注射庆大霉素治疗梅尼埃病的疗效和副作用。方法 :对 13例单侧梅尼埃病患者行患侧鼓室内注射庆大霉素 0 .5ml(2 6 .7g/L) ,每周 1次 ,共 2次 ,随访 2年以上。采用 1996年上海会议制定的梅尼埃病诊断依据及疗效分级标准诊断及判定疗效。结果 :治疗后 18～ 2 4个月 ,眩晕完全或基本控制 12例 ,有效率为 92 .3%。治疗后 2周 ,0 .5kHz、1.0kHz、2 .0kHz和 3.0kHz平均听阈较治疗前无明显变化 ;8.0kHz听阈升高 3例 (2 3.1% ) ;治疗后 18～ 2 4个月 ,0 .5kHz、1.0kHz、2 .0kHz和 3.0kHz平均听阈提高 4例 (30 .8% ) ,8.0kHz提高 5例 (38.5 % ) ,耳鸣无明显变化。结论 :鼓室注射庆大霉素是一种值得提倡的经济、简便、能有效控制梅尼埃病眩晕发作的治疗方法 ,但对听力也有一定的损坏作用 。
Objective:To investigate the effect and toxicity of intratympanic gentamicin injection therapy for intractable vertigo of Meniere's disease.Method:Thirteen patients diagnosed of unilateral Meniere's disease were given gentamicin 0.5 ml ( 26.7 mg/ml) intratympanically once a week for two weeks. All the patients were followed-up for at least two years. The result was monitored using the criteria set by Chinese Otorhinolaryngological Academy and Editorial Board of Chinese Journal of Otorhinlolaryngology in 1996.Result:Complete or substantial vertigo control was achieved in 12 patients ( 92.3%). Two weeks after treatment,the pure tone ( 0.5 kHz, 1.0 kHz, 2.0 kHz, 3.0 kHz)average hearing threshold had no significant change. 8.0 kHz hearing threshold increased significantly in 3 patients( 23.1%). 18～24 months after treatment,the hearing threshold increased significantly in 9 patients respectively.No patient felt improved in tinnitus.Conclusion:Intratympanic gentamicin injection is a simple and cost-effective means for controlling intractable vertigo spelling of Meniere's disease, but it also has some toxic effect to hearing.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2004年第1期14-16,共3页
Journal of Clinical Otorhinolaryngology
关键词
梅尼埃病
庆大霉素
鼓室
Meniere's disease
Gentamicin
Tympanum
