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p53和PCNA在非小细胞肺癌中的表达及其意义 被引量:1

Expression of p53 and PCNA in non-small cell lung cancer and its clinical significance
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摘要 目的 探讨人非小细胞肺癌(NSCLC)中p53、细胞增殖核抗原(PCNA)的表达水平与肺癌浸润和预后的关系。方法 应用免疫组织化学ABC法对65例人非小细胞肺癌中p53、PCNA的表达水平进行研究,用Kaplan-Meier法进行分析。结果 非小细胞肺癌中p53表达率为80.0%(52/65),高表达率为60.0%(39/65),高表达的NSCLC患者生存期小于低表达患者(P>0.05);PCNA表达率为86.2%(56/65),高表达率为60.0%(39/65),高表达的NSCLC患者生存期明显小于低表达患者(P<0.05)。p53与PCNA共阳性率为38.5%(25/65),共阴性率为15.4%(10/65),p53与PCNA共阳性的NSCLC患者生存期明显小于共阴性的患者(P<0.05)。结论 p53、PCNA与非小细胞肺癌发生、发展有关,其联合表达是NSCLC患者预后不良的标志。 Objective To explore the expression levels of p53 gene and proliferating cell nuclear antigen (PCNA)and their relationship to invasion and prognosis of human non-small cell lung cancer(NSCLC) .Methods The expression levels of p53 and PCNA were examined by immunohistochemistry in 65 non-small cell lung cancer samples. Kaplan-Meier method was used for analysis. Results The positive immunostaining rate for p53 was 80. 0%(52/65) and high-expression rate was 60.0% (39/65) . Patients in the group with low expression seemed to have longer survival time than those in the high-expression group, but the difference was not significant ( P > 0.05) . The positive immunostaining rate for PCNA was 86.2%(56/65) ?and the high-expression rate was 60.0% (39/65) .Patients in the low-expression group obviously lived longer than those in high-expression group, and the difference was significant P < 0.05). The positive immunostaining rate for both p53 and PCNA was 38.5 % (25/ 65) and the negative immunostaining rate for both p53 and PCNA was 15.4%(10/65) .Patients in the group with negative immunostaining for both p53 and PCNA obviously lived longer than those in the positive immunostaining group, and the difference was significant P < 0.05) . Conclusion p53 and PCNA are associated with the occurrence and development of NSCLC. The expression of p53 and PCNA is a marker of the poor prognosis in the non-small cell lung cancer.
出处 《中国肿瘤临床与康复》 2003年第5期405-407,共3页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 肺肿瘤 P53 细胞增殖核抗原 预后 Lung neoplasm p53 PCNA Prognosis
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