摘要
目的：筛选较佳的双氯芬酸钠（ＤＳ）离子导入明胶海绵。方法：制备４种不同处方的含有双氯芬酸钠溶液的明胶海绵，采用改良Ｆｒａｎｚ扩散池进行药物明胶海绵体外离子导入实验。结果：４种不同处方的含药明胶海绵的透皮速率分别为６３．４±８．０２、５６．０±５．８２、６１．２±６．１４和６０．８±５．２５μｇ／ｃｍ２／ｈ。明胶海绵吸收ＤＳ溶液２０ｍｉｎ后，其电阻较不含药海绵显著下降，采用较低电压即可维持所需电流强度。加入吸附剂的含药海绵在导入前、后明胶海绵的ｐＨ值几乎不发生改变。结论：按处方Ⅳ制得的双氯芬酸钠明胶海绵的外观、柔韧性均较好。
Objective:To select the satisfactory formula of diclofenac sodium gel.Methods:Four formulae of gelatin were prepared and the modified Franz difussion cells were employed in the transdermal iontophoretic experiments of these gelatins.Results:The fluxes of these four formulae were 63.4±8.02、56.0±5.82、61.2± 6.14 and 60.8±5.25 μg/cm 2/h respectively.There were no significant differences among them.The resistence of gelatin was reduced significantly after the gelatin absorbed the drug solution in 10 minutes.The study also demonstrated that if the adsorbent was added to the gelatin,there were no marked pH changes in gelatin before and after iontophoretic experiment.Conclusion:Formula Ⅳ is the best of all gelatins selected which has a good appearance and flexibility,and this gel can reduce the change of pH value caused by the electrical field.
出处
《浙江大学学报（医学版）》
CAS
CSCD
1999年第2期56-58,63,共4页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金
浙江省卫生厅基金
