摘要
目的 :探讨残胃癌中nm2 3、p53、C erbB 2癌基因产物的表达与临床病理特点的关系。方法 :应用免疫组织化学S P法检测52例残胃癌中nm2 3、p53、C erbB 2癌基因产物的表达。结果 :52例残胃癌中 ,nm2 3阳性率 65 4% ,p53阳性率 2 5 % ,C erbB 2阳性率40 4%。三者的阳性表达水平与肿瘤的病理组织学分级差异显著。结论 :nm、p53、C erbB 2在残胃癌中的表达与肿瘤组织学分级有关 ,三者均可作为判断肿瘤恶性度的客观指标。残胃癌中C erbB 2、p53过表达nm2 3低表达是其易于浸润和转移的原因之一。C erbB
Purpose: To study the relationship between the expression of nm23,p53 and C-erbB-2 protein and the clinicopathologic properties in stump gastric carcinoma (SGC). Methods: The expression of nm23,p53 and C-erbB-2 protein in 52 cases of SGC were examined using S-P immunohistochemical method. Results: The positive cxpression of nm23,p53 and C-erbB-2 protein was 65.4%,25% and 40.4%,respectively. There was significant difference between those protain expression levels and tumor's histological grades. Conclusion: The expression of nm23,p53 and C-erbB-2 shows positive correlation with tumor's histological grades. They can be used as objective parameters for the determination of maligant degree in stump gastric carcinoma. The results suggest that C-erbB-2 and p53 protein overexpression and nm23 protein lowexpression may be one of the causes of SGC biological feature.Serial tests of C-erbB-2,nm23 and p53 protein can be used the markers to evaluate the patients prognosis.
出处
《临床消化病杂志》
2003年第4期164-165,共2页
Chinese Journal of Clinical Gastroenterology
