摘要
目的 探讨血管内皮生长因子与小儿肾母细胞瘤的临床分期、病理类型及转移和预后之间的内在联系。方法 采用免疫组织化学过氧化物酶法(SABC法),对31例肾母细胞瘤组织标本进行血管内皮生长因子表达的检测,并对21例患儿进行了2年以上的随访。结果 肾母细胞瘤组织中,血管内皮生长因子的总阳性表达率为67.74％(21/31)。其中,肿瘤的临床分期之间和病理类型之间血管内皮生长因子的阳性表达均无统计学意义(P>0.05),而与肿瘤是否发生肺部转移密切相关(P<0.05)。血管内皮生长因子表达阳性2年生存率为27.27％(3/11),而阴性表达者生存率则为80.0％(8/10),二者比较存在显著性差异(P<0.05)。结论 小儿肾母细胞瘤组织中存在血管内皮生长因子的高表达,与肿瘤的临床分期、病理类型无关,而与肿瘤细胞的侵袭能力密切相关。其有可能成为肾母细胞瘤预后的重要指标之一。
Objective To study the expression of vascular endothelial growth factor(VEGF) and its
relationship among clinical stage, pathological type, and prognosis of Wilms' tumor. Methods From
March 1997 to March 2002, 31 cases (23 boys, 8 girls) aging 6months to 8 years (mean 4. 5yr) with
Wilms' tumor were operated. The classifications (NWTS-3) were stage Ⅰ in 12 cases, stage Ⅱ in 9, stage
Ⅲ in 5 and stage Ⅳ in 5. Of them, 5 cases had pulmonary metastasis and 21 cases were followed-up over
2 years. The expression of VEGF in the specimens were detected by immunohistochemical method (SABC
technique). Results The positive expression rate of VEGF in Wilms' tumor tissues was 67.74% (21/
31). The positive expressions of VEGF made no significant difference among different clinical stages and
pathological types (P>0. 05). The complicated lung metastasis was closely related with the positive expres-
sion of VEGF (P≤0. 05). The 2-year survival rate of VEGF positive group was 27. 27 % (3/11), which
was significantly lower than that in negative expression group (8/10). Conclusions The high expression of
VEGF is closely related to the invasive ability of tumor. The positive expression might be a prognostic
marker in children with Wilms' tumor.
出处
《中华小儿外科杂志》
CSCD
北大核心
2003年第6期496-498,共3页
Chinese Journal of Pediatric Surgery
