肝性脑病发病机理及治疗新进展
被引量:4
New development on pathogenesis and treatment of hepatic encephalopathy
摘要
肝性脑病(hepatic encephalopathy,HE)指各种严重肝脏疾病所致的代谢紊乱,影响中枢神经系统功能,出现以精神-神经症状为主的一种肝脑综合征.肝性脑病的治疗近十年来仍无重大突破.为了更好地研究肝性脑病,需要规范其研究方法.
出处
《临床药物治疗杂志》
2003年第4期21-24,共4页
Clinical Medication Journal
参考文献10
-
1[1]Hazell AS, Butterworth RF. Hepaticencephalopathy: an update of pathophysiologic mechanisms. Pro Soc Exp Bio Med, 1999,222:99 ~112 被引量:1
-
2[2]Vallone R, Zeneroli ML, Venturinil I, et al Endogenous benzodiazepine- like compounds and diazepam binding in serum of patients with liver cirrhosis with and without overt encephalophathy. Gut,1998,42 (3) :861 被引量:1
-
3[3]Maddison JE, Dodd PR, Johnston GAR, Farrell GC. Brain γ - aminobutyric acid receptor binding is normal in rats with thioacetanide induced hepatic encephalopathy despite elevated plasma γ - aminobutyric acid - like activity. Gastroenterology, 1987,93:1062 ~ 1063 被引量:1
-
4[4]Kaneko K, Kurumaji A, Watanabe A, et. Changes in high k+ -evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide _ induced hepatic encephalophathy. J Neural Trasm,1998,105( 1 ) :13 被引量:1
-
5[5]Yurdaydin C, Karavelioglu D, Onaran O, et al. Opioid receptopr ligands in human hepatic encephalopathy. J Hepatol, 1998,29(5) :796 被引量:1
-
6[6]Lee J, Lacomis D, Comu S, et al. Acquined hepatiocenebral degeneration: MR and pathologic findings. AJNR , 1998,19:485 ~487 被引量:1
-
7[8]Williams R, James OF, Warnes Tw, et al. Eavaluation of the efficacy and safety of rifaximin in the treatment of hepatic encephalopathy:double - blind, randomized, dose - finding multi - centre study. Eur J Gastroenterol Hepatol, 2000, 12:203 ~208 被引量:1
-
8[9]Rose C, Michalak A, Rao KV, et al. L- ornithine -L- aspartate lowers plsasma and cerebrospinal fluid ammonia and prevents brain edema in rate with acute liver failure. Hepatology, 1999,30 (3) :636 被引量:1
-
9[10]Barbaro G, Di Lorenzo G, Soldini M, et al. Flumazenil for hepatic encephalopathy grade Ⅲ and Ⅳa in patients with cirrhosis: an Italian multicenter double - blind, placebo - controlled, cross - over study.Hepatology, 1998,28:374 ~378 被引量:1
-
10[11]Sakurabayashi S, Sezai S, Yamamoto Y, et al. Embolization of portal -systemic shunts in cirrhotic patients with chronic recurrent hepatic encephalopathy. Cardiovasc Intervent Radiol, 1997,20:102 ~ 104 被引量:1
同被引文献28
-
1陈德珍,张秀辉,万仕琼,朱正贤.肝硬变脑水肿的临床病理[J].临床肝胆病杂志,1993,9(1):23-25. 被引量:14
-
2魏陆海,孙维洋.代谢组学与中药现代研究[J].山东中医药大学学报,2006,30(4):336-338. 被引量:10
-
3王喜军,孙文军,孙晖,吕海涛,邹迪新,吴泽明,王萍,刘莲,吴修红.CCL_4诱导大鼠肝损伤模型的代谢组学及茵陈蒿汤的干预作用研究[J].世界科学技术-中医药现代化,2006,8(6):101-106. 被引量:68
-
4李后开,王一煌,贾伟,周明眉,刘平.药物基因组学、药物代谢组学与辨证施治[J].世界科学技术-中医药现代化,2007,9(2):120-126. 被引量:12
-
5Blei AT, Cordoba J. Hepatic encephalopathy[ J]. Am J Gastroenterol, 2001,96 : 1968 - 1976. 被引量:1
-
6廖艳,彭双清,颜贤忠,张立实,董延生,陈合兵,赵剑宇.利福平致肝脏毒性的代谢组学特征研究[J].中国新药杂志,2007,16(16):1260-1265. 被引量:6
-
7Nava LE, Delgadillo AT. Minimal hepatic eneephalopathy [ J ]. Ann Hepatol,2011,10 ( Suppl 2) :50 - 54. 被引量:1
-
8Zhao X, Zhang Y, Meng X, et al. Effect of a traditional Chi- nese medicine preparation Xindi soft capsule on rat model of acute blood stasis:a urinary metabonomics study based on liquid chromatography-mass spectrometry [ J ]. J Chrom- atogr B Analyt Technol Biomed Life Sci, 2008,873 ( 2 ) : 151 - 158. 被引量:1
-
9Yap IK, Li JV, Saric J, et al. Metabonomic and microbiolog- ical analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse [ J ]. J Proteome Res,2008,7(9) :3 718 -3 728. 被引量:1
-
10Heijne WH, Lamers R J, van Bladeren PJ, et al. Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis [ J ]. Toxicol Pathol, 2005,33 (4) : 425 - 433. 被引量:1
引证文献4
-
1邓建奇.纳洛酮治疗肝硬化合并肝性脑病50例临床疗效观察[J].国际医药卫生导报,2005,11(8):70-71. 被引量:2
-
2麻继锋,张莲.纳洛酮治疗肝性脑病的临床疗效观察[J].中国厂矿医学,2008,21(1):68-68. 被引量:1
-
3倪琴.纳洛酮治疗肝性脑病56例临床效果分析[J].求医问药(下半月刊),2012,10(1):89-90.
-
4姚春,张伯礼.中医药对轻微型肝性脑病代谢组学影响的研究现状[J].广西医学,2012,34(6):768-770. 被引量:1
二级引证文献3
-
1秦万龙,张静,李伦,李江,田金徽.纳洛酮对肝性脑病疗效的系统评价[J].兰州大学学报(医学版),2009,35(3):55-59. 被引量:3
-
2吴志金,姜仁早.纳洛酮联合复方麝香注射液治疗肝硬化合并肝性脑病[J].现代中西医结合杂志,2012,21(17):1869-1870. 被引量:2
-
3楼红玲,白雪冰,邓碧珠.通腑开窍方联合食醋保留灌肠治疗肝性脑病的临床观察[J].广西医学,2017,39(3):357-359. 被引量:9
-
1肖扬,陈成伟.肝性脑病的新认识[J].肝脏,2002,7(3):201-202. 被引量:10
-
2孙洪清,骆成渝.慢性重型肝炎预后因素分析[J].上海预防医学,2001,13(1):26-27. 被引量:1
-
3王秀荣,刘丽.暴发性肝炎、肝脑综合征、肝昏迷一例[J].吉林医学信息,1994(11):48-48.
-
4刘志立.门冬氨酸鸟氨酸联合乳果糖治疗肝性脑病30例临床观察[J].中国煤炭工业医学杂志,2012,15(6):873-874. 被引量:3
-
5刘凤莲,刘刚.门冬氨酸鸟氨酸联合醒脑静治疗肝性脑病29例[J].浙江中医杂志,2012,47(8):623-623. 被引量:5
-
6刁军巧.肝性脑病健康教育的探讨[J].现代医药卫生,2007,23(2):254-255.
-
7石亮,钱菁菁,陈丽玲,林向阳,陈晓东.肝性脑病患者血清S100B和神经元特异性烯醇酶的应用研究[J].中华临床感染病杂志,2010,3(2):105-107. 被引量:2
-
8王惠军,薛玉良.氯胺酮对中枢神经系统功能的影响[J].国外医学(麻醉学与复苏分册),2003,24(4):234-237. 被引量:10
-
9黎艳,杜芸,梁务清.外伤性癫痫患者及家属的健康教育[J].医学文选,2005,24(1):49-50. 被引量:2
-
10高晓玲.肝性胸水临床特征分析[J].当代医学,2012,18(30):53-54. 被引量:2