摘要
目的与方法 :通过观测、对比使用清开灵注射液或苯巴比妥前后癫痫点燃模型大鼠海马组织谷氨酸 (Glu)、γ 氨基丁酸(GABA)的含量以及神经元形态学的改变 ,以探索癫痫的发病机制以及清开灵注射液对癫痫的干预作用。结果 :所有大鼠均达到癫痫模型点燃标准。使用清开灵的中药干预组与点燃模型组比较 ,Glu含量明显下降 ,GABA含量则明显升高 (P <0 .0 1) ,同时神经元形态学改变明显好转。结论 :清开灵注射液可能具有减轻痫性发作 。
Objective To discuss mechanisms of amino acid neurotransmitter in formation and developing process of epilepsy, and find out a new pathway of epileptic therapeutics.Methods 40 rats were evenly devided into 4 groups: kindled group,Qingkailing group,phenobarbital group and blank control group. Pentetrazole was injected into abdominal cavity to establish epileptic rat models. HPLC was used to detect the content of glutamate(Glu)and γ-aminobutyric acid(GABA)in epileptic rats, and followed by the comparison of Qingkailing parenteral solution and barbenyl intervention. Results All rats reached kindled standard. Then Glu content of Qingkailing group was lower than that of kindled model group, while GABA was higher(P<0.01). Conclusion Qingkailing parenteral solution seems to resolves epilepsy and protect neurons.
出处
《东南大学学报（医学版）》
CAS
2003年第6期380-383,共4页
Journal of Southeast University(Medical Science Edition)
