摘要
目的 :通过阴茎海绵体血生化指标的检测 ,探索缬沙坦 (Valsartan)在阴茎海棉体平滑肌中的作用。方法 :选取 5 6例勃起功能障碍病人 ,给予缬沙坦口服两个月 ,前后血气分析及血 No含量测定 ,所有病例均分为 1)前列腺素E1 尿道给药 +缬沙坦 (n=15 ) ,2 )安慰剂 +缬沙坦 (n=2 0 ,3)前列腺素 E1 尿道给药 +安慰剂 (n=2 1)三组进行对比。结果 :(1)三组病人阴茎海绵体血液 No含量接受实验前后均有明显变化 ,而前列腺素 E1 尿道给药 +缬沙坦组作用效果优于其他两组。 (2 )血气分析方面 :两种药物使用前后对比 ,PO2 及 O2 Sat均存在显著性差异 ;前列腺素 E1 尿道给药+安慰剂 ,安慰剂 +缬沙坦使用前后 p H值无显著差异 ,而前列腺素 E1 尿道给药 +缬沙坦 ,前后有显著性差异 ,而这两种制剂效果之间相比 ,p H,PO2 值之间存在显著性差异 ,O2 Sat值之间无显著性差异。结论 :前列腺素 E1 尿道给药 +缬沙坦联合使用可成为一良好的 No供体 ,而 No可导致阴茎海绵体平滑肌舒张 ,血流增加 。
Objectives:To evaluate the efficacy of NO in sponge smooth muscle with blood biochemical study.Methods: 56 ED patients were recruited in this study. PGE 1 and Valsartan is used in each patient.The blood gas analysis and determination of sera NO in the penis are performed beford and after administer.Meanwhile comforts are used for control group. Results:(1)NO elevated after in three groups. The effects of administer PGE 1 plus Valsartan are better than other two group.(2) PO 2 and O 2Sat increased in three groups after administer.There is no statistical difference of pH before and after administering,and there is statistical significance of pH in control group.Compared PGE 1 plus Valsartan with other two group, there is no statistical difference of pH and PO 2.There is no statistical significance of O 2Sat between two groups. Conclusions:PGE 1 plus Valsartan is a better NO donor.NO can facilitate the relaxation of smooth muscle and blood inflow. Compared with other agents,its effects on simulation of endogenous vasodilation with NO is consistant with body sphysioglical mechanism.
出处
《海南医学》
CAS
2001年第3期22-24,共3页
Hainan Medical Journal
