摘要
目的：考察麝香保心丸中冰片的体外溶出行为。方法：采用气相色谱法测定冰片的含量，并在密闭条件下通过小杯桨法进行体外溶出度的研究。结果：溶出过程中的密闭条件，可有效防止冰片在溶出过程中的挥散损失，麝香保心丸中的冰片，在人工胃液、人工肠液、蒸馏水中的溶出行为差异很大。在人工肠液中溶出速率最快，累积溶出百分率最大；在人工胃液中溶出速率最慢，累积溶出百分率次于在人工肠液中；在蒸馏水中溶出速率处于前两者之间，而累积溶出百分率最小。结论：气相色谱法快速、简便、准确。
AIM To study the dissolution of borneol in traditional Chinese drug Shexiang Baoxin Wan in vitro.METHODS The gaschometgraph (GC) method was used for determination of borneol.The in vitro dissolution of borneol in Shexiang Baoxin Wan was performed with paddle method in the airtight vessel.RESULTS The airtight vessel can effectively reduce the loss of borneol in the process of dissolution testing.The dissolution characteristics of borneol of Shexiang Baoxin Wan were remarkly different in three kinds of dissolution medium-simulated gastric juice, simulated intestinal juice, distilled water.The dissolution speed of borneol was most fast in the simulated intestinal juice, but the most slow in the simulated gastric juice.The accumulate dissolution percentage of borneol was the highest in the simulated intestinal juice,but the lowest in the distilled water.CONCLUSION This GC method was found to be simple,quick and accurate for determination of borneol.The remarkable difference of the in vitro dissolution characteristics of borneol of Shexiang Baoxin Wan in the three kinds of dissolution medium could result from the complements and (or) the other medicinal materials in Shexiang Baoxin Wan.
出处
《解放军药学学报》
CAS
1999年第2期17-21,共5页
Pharmaceutical Journal of Chinese People's Liberation Army
