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肿瘤坏死因子在肝缺血/再灌注损伤中的作用及异丙酚的干预 被引量:5

Role of tumor necrosis factor in reperfusion injury following hepatic ischemia and effect of propofol
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摘要 目的 探讨肿瘤坏死因子(TNF)在肝缺血/再灌注损伤(HIRI)中的作用及异丙酚对其的影响。方法 选择HIRI实验兔及肝癌手术患者,观察血浆TNF含量、谷丙转氨酶(ALT)活性、肝形态学的变化及异丙酚对上述指标的影响。结果 HIRI期间,TNF和ALT明显升高(P均<0.01),两者呈显著正相关(实验兔r=0.912,P<0.01;患者r=0.535,P<0.01),肝形态学发生异常变化;使用异丙酚后,上述指标的异常变化显著减轻,其差异有显著性意义(P<0.05和P<0.01)。结论TNF是HIRI的重要发病因素,异丙酚可通过降低TNF减轻HIRI。 Objective To explore the role of tumor necrosis factor(TNF) in rabbit and humans during hepatic ischemia-reperfusion injury (HIRI)and the effect of propofol on it. Methods Changes of several prameters and the effect of propofol on it were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery, parameters of which included TNF, alanine aminotransferase (ALT) and changes of hepatocytes morphology. Results TNF content and ALT activities significantly increased(P<0. 05and P<0. 01), and the abnormal changes of hepatocytes morphology were obvious during HIRI. There was positive correlation between the changes of TNF and ALT (rabbits, r=0.912, P<0.01 and patients, r=0. 535, P<0. 01)during HIRI with treatment of propofol, the abovementioned abnormal changes of all the parameters and hepatocytes morphology were all alleviated remarkably(P<0.05 and P<0.01). Conclusion TNF might be one of the primary causes for HIRI, and propofol could attenuate HIRI by eliminating TNF.
出处 《中国急救医学》 CAS CSCD 北大核心 2003年第11期783-784,共2页 Chinese Journal of Critical Care Medicine
基金 浙江省跨世纪学术和技术带头人 温州市"551人才工程"培养基金 浙江省卫生厅科研基金联合资助项目(No.992086 98018 98A087)
关键词 肝缺血/再灌注损伤 肿瘤坏死因子 异丙酚 Hepatic ischemia--reperfusion injury Tumor necrosis factor(TNF) Propofol
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