摘要
目的 :探讨儿童哮喘气道炎症的可能机制。方法 :对 34例哮喘急性发作儿童及 2 5例正常儿童进行痰液诱导 ,对痰液中炎性细胞、IL - 8水平进行检测。结果 :哮喘急性发作组痰液嗜酸性粒细胞 (EOS)、中性粒细胞 (N)、IL - 8水平均高于正常对照组儿童。哮喘急性发作组中性粒细胞数超过总细胞数 5 0 %以上 5例、嗜酸性粒细胞数超过总细胞数 5 0 %以上 2例。哮喘急性发作组IL - 8与中性粒细胞水平正相关。结论 :哮喘急性发作儿童气道炎症呈多样性。IL -
Aim: To infer possible mechanisms of airway inflammation in children with acute asthma. Methods: The sputum was induced from 34 children with acute asthma and 25 healthy children. Inflammatory cells and interleukin-8(IL-8) level in sputum were detected.Results: The levels of eosinophil, neutrophil, and IL-8 in acute asthma group were significantly higher than control group. In acute asthma group neutrophils accounted for more than 50% of total sputum cells in 5 samples and eosinophils accounted for more than 50% of total sputum cells in 2 samples. In acute asthma group the IL-8 level positively correlated with neutrophils. Conclusion: There is heterogeneity of airway inflammation in children with acute asthma. IL-8 may mediate airway neutrophilia in acute asthma.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2003年第6期957-958,共2页
Journal of Zhengzhou University(Medical Sciences)
关键词
哮喘
儿童
痰液
炎性细胞
IL-8
asthma
children
sputum
inflammatory cell
interleukin-8
