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胰岛素泵治疗继发性失效2型糖尿病临床研究 被引量:1

Therapeutical effect of continuous subcutaneous insulin infusion by insulin pump on Type 2 diabetic patients poorly controlled with sulfonylurea failure
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摘要 目的 比较磺脲类药物失效(sulfonylurea failure,SF)的 2型糖尿病患者胰岛素泵连续皮下输注治疗(continu-ous subcutaneous insulin infusion,CSⅡ)组和多次注射胰岛素组(multiple subcutaneous insulin injection,MSⅡ)血糖控制的疗效和安全性。方法 采用对照研究方法探讨CSⅡ和MSⅡ两种治疗方法在控制血糖、胰岛素剂量、低血糖的发生率的差异。结果 GDⅡ组治疗达到理想血糖控制的疗效和所需的时间明显短于MSⅡ组(P<0.01);GSⅡ组治疗达到理想血糖控制所需的胰岛素量明显少于MSⅡ组(P<0。01);CSⅡ组低血糖发生率低于MSⅡ组。结论CSⅡ治疗能缩短达到理想血糖控制的时间,有效地降低餐后2小时血糖;减少了胰岛素用量;减少了低血糖的发生。囚此,CSⅡ疗法对SF的2型糖尿病患者理想血搪控制比MSⅡ疗法更快、更有效,且使用胰岛素剂量更小,更安全。 Objective To investigate the therapeutic effect and safety of continuous subcutaneous insulin in- fusion( CSⅡ) by insulin pump and multiple subcutaneous insulin injection( MSⅡ) in controlling blood glucose on type 2 diabetic patients with sulfonylurea failure (SF) . Method The differences of blood glucose level, insulin dosage , GA, HbAlc and hypoglycemic episodes both in CSⅡ Coup with insulin pump and MSII Group are compared by a match study. Results The time needed for reaching well controlled blood glucose levels in diabetic patients with SF in CSⅡ group was significantly shorter and than that of patients in MCII group (p <0.01) ;the insulin dos- age needed for reaching well controlled blood glucose level in CSⅡ group was obviously less than that of the MSⅡ group (p<O.O1) and hypoglycemia episodes of CSII group was also lower than that of MSⅡ group (p<O.Ol). Conclusion CSⅡ can, as a new intensive therapy for type 2 diabetic patients with SF and compared with MSⅡ, shorten the duration of insulin treatment, reduce insulin dosage and hypoglycemic episodes as well as is more effec- tive and safe.
出处 《中国热带医学》 CAS 2001年第3期235-237,共3页 China Tropical Medicine
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  • 1叶山东.非胰岛素依赖型糖尿病药物治疗现状[J].国外医学(内科学分册),1995,22(8):334-338. 被引量:5
  • 2Genuh, S. Management of the abult onset diabetic with sulfonylurea failure. Endo Metab clinics Nouth. Am 1992; 21:351~ 69. 被引量:1
  • 3Pugh, J. A, Wagner M. L, Sawyer J. Is combinafion solfonylurea and insulin therapy useful in NIDDM Patients? Diabetes care 1992; 15: 953~ 59. 被引量:1
  • 4Yki - Jarvien H, Helve E, Sane T. et al. lnsulin inhibition of overnight ghucose production and gluconeo genesis. from Lactate. In NIDDM. Am. J. Physiol 1989 ;256: E732. 被引量:1
  • 5American Diabetes Association: Implications of the Diabetes Control and Complications Trial. Diabetes Care 2000, 23(Suppl 1):S24. 被引量:1
  • 6American Diabetes Association : Implications of the United Kingdom Prospective Diabetes Study Diabetes Care 2000, 23(Suppl 1) :S27. 被引量:1
  • 7Tho Diabetes Control and Complications Trial Research Group. The absence of glycemic threshold for the developments of long - term complications: The perspective of the Diabetes Control and Complications Trial. Diabetes 1996;45:1289. 被引量:1
  • 8Kaakso M. Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 1999 ;48:937. 被引量:1
  • 9Countinho M, Gerstein HC, Wang Y, et al: The relationship between glucose and incident cardiovascular events. Diabetes Care 1999;220:223. 被引量:1
  • 10BJ φ mholt JV, Erikssen G, Aaser E: Fasting blood glucose:An underestimated risk factor for cardiovascular disease. Results from a 22 - year follow - up of healthy nondiabetic man. Diabetes Care 1999;22:45. 被引量:1

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  • 1李延兵,廖志红,许雯,姚斌,邓婉萍,欧香忠,胡国亮,翁建平.胰岛素泵治疗对初诊2型糖尿病患者糖脂代谢的影响[J].中山大学学报(医学科学版),2004,25(4):359-363. 被引量:40
  • 2刘超.利用先进科技引领糖尿病强化治疗达标——胰岛素泵临床应用指导与精细处理[J].实用糖尿病杂志,2005,1(3):11-13. 被引量:22
  • 3Bode BW, Steed RD, Davidson PC. Reduction in severe hypoglycemia with long - term continuous subcutaneous insulin infusion in type IDiabetes. Diabetes Care, 1996; 19:324 -327. 被引量:1
  • 4Chantelau E, Schiffers T, Schutze. J, etal. Effect of patient -selected intensive insulin therapy on quality of life. Patient Edu Couns, 1997;30:167 - 173. 被引量:1
  • 5steven Milli, Kelley Martin. Treatment of Type 2 Diabetes in Childhood,Using a very- Low- Calorie Diet. Diabetes Care,2004 ; 27(2) : 348 - 353. 被引量:1
  • 6Elizabetha. Doyle, Stuarta Weinzimer, A Randomize, d, Prospective Trial Companlng the Efficacy of Continunus Subcutaneous lnsuin infusion With Multiple Daily injections Using insulinGlargine. Dialx- es Carc,2004;27(7) : 1554 - 1558. 被引量:1
  • 7David Simmons, Colin F. Thompson. Use of Insulin Pumps in Pregnancies Complicated by type 2 Diabetes and Gestational Diabetes in a Multiethnic Community. Diabetes Care,2001,24(12) :2078 - 2{)82. 被引量:1
  • 8Ilkova H, Glaster B, Tunckale A, et al. Induction of long -term glyeemic control in newly diagnosed Type 2 patients by transistent intensive insulin treatment. Diabetes Care, 1997;20.1353 - 1356. 被引量:1
  • 9Saha ME, Huuppone T, Mikael K (J). Pediatr Endocrinol Metab,2002; 15(7) : 1005 - 1010. 被引量:1
  • 10Pickup J ,Keen H. Diabetes Care,2002,25(3) :593 - 598. 被引量:1

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