摘要
咪唑和氯乙酸乙酯通过非均相反应合成咪唑乙酸乙酯 ,酸性水解得到咪唑乙酸盐酸盐 ,和三氯化磷、磷酸反应后再水解制得唑来膦酸。原料价廉易得 ,操作简便 ,反应总收率 36 %。
Zoledronic acid was synthesized from imidazole and ethyl chloroacetate by heterogeneous reaction and hydrolysis to give imidazol-1-acetic acid hydrochloride which reacted with phosphorus trichloride and phosphoric acid followed by hydrolysis with an overall yield of 36%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第11期543-544,共2页
Chinese Journal of Pharmaceuticals
关键词
唑来膦酸
高钙血症
合成
zoledronic acid
hypercalcemia of malignancy (HCM)
synthesis
