摘要
目的:应用两种艾灸疗法治疗两肾一夹肾血管性高血压大鼠(2K1C-RHR),评价这两种艾灸疗法的降压作用,并对其降压机理作初步的探讨。方法:建立2K1C-RHR模型,并将其随机分为六组:灸法Ⅰ组(百会、神阙、足三里)、灸法Ⅱ组(关元、涌泉、足三里)、卡托普利组、灸法Ⅰ+卡托普利组、灸法Ⅱ+卡托普利组、高血压对照组,另设正常对照组。经过10天治疗后,测量血压,并测定血浆中内皮素(ET)、一氧化氮(NO)。结果:高血压对照组的收缩压(SBP)、舒张压(DBP)明显高于正常对照组,各治疗组的SBP、DBP明显低于高血压对照组(P<0.01),各治疗组间则没有明显差异(P>0.05)。血浆NO含量各组间没有明显差异(P>0.05)。各治疗组与正常对照组的血浆中ET含量明显低于高血压对照组(P<0.01)。各治疗组ET/NO比值接近正常对照组(P>0.05)且明显低于高血压对照组(P>0.05)。结论:两种艾灸疗法有良好的降压作用,其降压机理与及纠正ET与NO的失衡状态有关。
Aim:To study the effect and mechanism of two kinds of moxi-bustion therapies in the treatment of two - kidney one - clip renovascu-lar hypertensive rats (2K1C - RHR) .Methods:2K1C - RHR male rats were randomly divided into six groups the moxibustion therapy Ⅰ (Bai-hui-Shenque - Zusanli) (the first group) ,the moxibustion therapy Ⅱ (Guanyan - Yongquan - Zusanli) (the second group), the captopril group (the third group), the moxibustioin therapy Ⅰ with captopril group (the forth group) ,the moxibustion therapy Ⅱ with captopril group (the fifth group) ,the hypertension grou (the sixth group) ,and the she-moperation group was used as the controlled group. After one course of treatment (ten days),caudal artery blood pressure of the rats (systolic blood pressure (SBP) and diastole blood pressure (DBF)) was measured, the level of, endothelin (ET) in blood samples was separately measured by immune radioactive assay, and the level of nitric oxide (NO) in blood samples was measured by colorimeteric method.Results: The blood pressure (SBP and DBP) of the hypertension group (the sixth group) was markedly higher than that of the others groups ( P < 0.01), while the evident difference of the blood pressure (SBP and DBP) was not founded among the five treatment groups and the control group ( P > 0.05). The level of ET in the hypertension group was significantly higher than in other groups, while the level of NO in all groups showed little changes (P >0.05) .Conclusion:The study confirmed that the two kinds of moxibustion therapies have the effect of reducing the blood pressure (SBP and DBP),which is associated with the improvement of the recovery of unbalance of ET and NO.
出处
《针灸临床杂志》
2003年第10期51-53,共3页
Journal of Clinical Acupuncture and Moxibustion
