摘要
目的 评价99Tcm N NOET{双 [N 乙氧基 ,N 乙基 (二硫代氨基甲酸脂 )氮化锝 ] (Ⅴ ) }静息心肌血流灌注显像诊断冠心病 (CAD)的临床价值。方法 可疑冠心病的 74例男性、12例女性 (平均年龄 5 5 .6± 11.5岁 )行门控静息心肌血流灌注显像和冠脉造影 (将冠脉管腔狭窄≥ 5 0 %定为病变血管 ) ,其中行99Tcm N NOET静息心肌显像 44例 (平均年龄 5 5 .9±11.6岁 ) ,行99Tcm MIBI静息心肌显像 42例 (平均年龄 5 5 .4± 11.5岁 )。前者于注药后 1h显像 ,后者于注药后 1～ 1.5h显像。结果 99Tcm N NOET和99Tcm MIBI诊断冠心病的灵敏度分别为 71.4%和 64 .7% (P >0 .0 5 ) ,特异性分别为 88.9%和 87.3 % (P >0 .0 5 ) ,两组间灵敏度和特异性均无显著性差异。结论 99Tcm N NOET与99Tcm MIBI静息心肌血流灌注显像对诊断冠心病具有一致性。
Objective To evaluate the value of the rest techenium 99m bis (N ethoxy, N ethyl dithiocarbamato) nitride ( 99 Tc m N NOET) gated SPECT myocardial perfusion imaging (GSPECT) for detecting coronary artery disease (CAD). Methods For evaluation of suspected CAD, 74 men and 12 women (mean age, 55.6±11.5years) underwent the rest GSPECT and coronary angiography(CAG, ≥50% luminal diameter stenosis was considered significant coronary stenosis).All of them underwent 99 Tc m N NOET ( n =44, mean age 55.9±11.6years) or techenium 99m sestamibi ( 99 Tc m MIBI, n =42, mean age 55.4±11.5years) for gated GSPECT. Rest SPECT imaging was began 1 hour after intravenous injection of 99 Tc m N NOET or 1 to 1.5 hour after the intravenous injection of 99 Tc m MIBI at rest. Results Sensitivities of 99 Tc m N NOET and 99 Tc m MIBI GSPECT for detecting CAD were 71.4% and 64.7%, respectively. The specificity for both imaging agents was 88.9% and 87.5%, respectively. No significant difference in sensitivities and specificities was noted for the two imaging agents( P >0.05). Conclusion GSPECT with 99 Tc m N NOET or 99 Tc m MIBI gives diagnostic information comparable to each other in patients undergoing rest protocal for assessment of CAD. GSPECT with 99 Tc m N NOET is clinically feasible in detecting coronary artery disease. [
出处
《中国医学影像技术》
CSCD
2003年第9期1125-1127,共3页
Chinese Journal of Medical Imaging Technology
