摘要
作者用4种稳定性核素标记的支链氨基酸和芳香氨基酸对正常人与重型病毒性肝炎(重型肝炎)患者进行示踪动力学的研究。结果显示重型肝炎患者苯丙氨酸的血浆代谢库增大,而3种支链氯基酸的血浆库则减少。因此为了有效地纠正肝病时血浆氨基酸的不平衡,一方面需采用氨基酸制剂滴注疗法,另一方面还需采取措施减少支链氨基酸的降解。
The metabolic kinetics of branched chain amino acids (BCAA) and aromatic amino acids (AAA) in normal subjects and patients with severe viral hepatitis as studied with 4 stable isotope labeled tracers. The results indicated that the plasmatic pool size of Phe was increased and those of ECAA (Val, Leu, ILe) were decreased in severe viral hepatitis. This suggested that BCAA enriched infusion is valuable and may decrease the degradation of BCAA.
出处
《上海医学》
CAS
CSCD
北大核心
1992年第3期144-146,共3页
Shanghai Medical Journal
关键词
重症肝炎
代谢动力学
放射性核素
Amino acids
Severe viral hepatitis
Metabolic kinetics
