摘要
目的 :研究黄连解毒汤及拆方中生物碱的含量和溶出率的变化。方法 :采用HPLC法对黄连解毒汤及折方中 4种生物碱 :小檗碱、药根碱、黄连碱、巴马汀的含量进行了测定。结果 :传统汤剂生物碱的溶出率较低 ,黄连和黄柏合煎生物碱呈现加和性 ,加入黄芩、栀子后生物碱含量显著下降。结论 :有效控制黄连解毒汤中生物碱类有效成分 ,应采用黄连的特有成分黄连碱的含量和 4种生物碱的比例作为质量控制指标。
Objective: To study the content of alkaloids in Huanglianjiedu Decoction and its disassemble prescription. Methods: The contents of four alkaloids such as berberine, jatrorrhizine, coptisine, palmatine in Huanglian jiedu Decoction and its disassemble prescription were determined by HPLC. Results: The content of four alkaloids extracted by tranditional decoction had a tendency to low. On the coutrary, when Rhizoma Coptis and Cortex Phellodendri were decocted together the quantity of alkaloids was additive, and when two herbs above decocted with Radix Scutella and Fructus Gardeniae the quantity of alkaloids decreased obviously. Conclusion:This study can provide a basis for establishing rational quanlitative standard for Huanglianjiedu Decoction.
出处
《中成药》
CAS
CSCD
北大核心
2003年第11期912-914,共3页
Chinese Traditional Patent Medicine
