摘要
目的观察长春瑞宾(NVB)联合异环磷酰胺(IFO)和顺铂(DDP)治疗晚期乳腺癌的疗效.方法有明确病理学诊断的晚期乳腺癌患者40例,采用NVB为25 mg/m2,第1、8天静脉滴注;IFO为1.3 g/m2,第1～5天静脉滴注;DDP为20 mg/m2,第1～5天静脉滴注.每21 d为1周期,至少治疗2个周期后评价疗效.结果完全缓解6例,部分缓解16例,总有效率55%;初治者有效率66.6%,复治者有效率40.8%.主要毒副反应为骨髓抑制,以白细胞下降为主(Ⅲ、Ⅳ度抑制率达40%).结论NVB联合IFO和DDP治疗晚期乳腺癌的疗效较好,且毒副反应可以耐受.
Objective To observe the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer. Methods Forty cases of pathologically confirmed stages Ⅲ-Ⅳbreast cancer were treated with combined chemotherapy including intravenously infused navelbine (25 mg/m 2 , days 1 and 8), ifosfamide (1.3 g/m 2 , days 1 to 5) and cisplatin (20 mg/m 2 , days 1-5), administered in cycles of 21 days. The therapeutic effect was assessed after at least two cycles were completed. Results Complete remission was achieved in 6 cases and partial remission in 16, with an overall responding rate of 55%. The main toxicity was bone marrow suppression manifested by grades Ⅲ-Ⅳleukopenia occurring at a rate of 40%. Conclusion Navelbine in combination with ifosfamide and cisplatin is effective and safe in the treatment of advanced breast cancer.
出处
《第一军医大学学报》
CSCD
北大核心
2003年第10期1088-1089,1092,共3页
Journal of First Military Medical University
关键词
长春瑞滨
异环磷酰胺
顺铂
联合治疗
晚期乳腺癌
breast neoplasms/drug therapy
tartrates
ifosfamide
cisplatin
drug therapy, combination
