摘要
目的 评价儿童哮喘患者血清微量元素检测指标的意义。方法 通过CBMdisc、中文全文数据库全面检索国内已发表的相关文献,检索策略:哮喘中国儿童患者与对照组血微量元素检测。资料收集和分析:由2位评价者按照上述检索策略收集文献,排除那些不符合选择标准要求的试验并进行Meta分析。结果 Zn、Fe、Mg、Ca下降分别为2.07 μmol/L(95％CI 1.57-2.57)、1.98μmol/L(95％CI 0.96-3.00)、0.10μmol(95％CI 0.07-0.13)、0.16 mmol/L(95％CI 0.10-0.22),有显著统计学意义(P<0.001);Cu、Mn增高分别为0.78 μmol/L(95％CI0.05-1.51)、0.02μmol/L(95％CI 0.01-0.04),有统计学意义(P<0.05)。结论哮喘患者存在微量元素不平衡,有必要开展更广泛研究和更深层的原因探索。
Objective: To evaluate the effect of trace elements in children serum examination in patients with asthma. Method: The search for all the related literature in CBMdisc has been made and Chinese full text database had been made as well. Selection criteria: Examination of serum trace element in Chinese children patients with asthma and control group. Data collection and analysis: A quantitative meta-analysis was carried out by two reviewers using updated information based on inclusion and exclusion criteria from all papers available. The meta-analysis was based on all trace elements. Results: The numbers of Zn, Fe, Mg and Ca in the patients were significantly less than those in the healthy control group 2. 07 μmol/L(95% CI 1. 57 - 2. 57), 1. 98 μmol/L(95% CI 0. 96 - 3. 00), 0. 10 μmol(95% CI 0. 07-0. 13), 0. 16 mmol/L(95% CI 0. 10 - 0. 22) ( P < 0. 001) respectively while the numbers of Cu and Mn in the patients were significantly more than those in the healthy control group 0. 78 μmol/L(95% CI 0. 05 - 1. 51).0. 02 μmol/L(95% CI 0. 01-0.04)(P < 0. 05) respectively. Conclusion: There were unbalanced trace elements in the Chinese children patients with asthma.
出处
《循证医学》
CSCD
2003年第1期18-21,共4页
The Journal of Evidence-Based Medicine
