摘要
目的 :探讨基质金属蛋白酶 -2 (MMP-2 )和组织基质金属蛋白抑制剂 -2 (TIMP-2 )在人甲状腺乳头状癌组织中的表达及其与浸润程度、淋巴结转移的关系。方法 :应用免疫组织化学 S-P法对 56例甲状腺乳头状癌组织及其癌旁正常甲状腺组织中 MMP-2和 TIMP-2表达情况进行检测。结果 :MMP-2和 TIMP-2在甲状腺乳头状癌组织中表达的阳性率分别为 76.8% (43 / 56)和 3 7.5%(2 1/ 56)。在癌旁正常甲状腺组织中表达的阳性率分别为 3 3 .9% (19/ 56)和 3 2 .1% (18/ 56) ,表明MMP-2在甲状腺乳头状癌中有较高表达率。同时 MMP-2和 TIMP-2的表达与浸润程度、淋巴结转移有显著相关性 (P<0 .0 5) ,与肿瘤大小无相关性。结论 :MMP-2和 TIMP-2的表达与甲状腺乳头状癌浸润程度、淋巴结转移密切相关 。
Objective:To study the expression of Matrix Metall oproteinase-2(MMP-2) and Tissue Inhibitor of Metalloproteinase-2(TIMP-2) in Papillary Thyroid Carcinomas(PTL) tissues and the relationship with degree of th e infiltration and lymph node metastasis.Methods:Using S-P immunohistochemical methods,we examined the e xpression of MMP-2 and TIMP-2 in 56 PTC tissues and adjacent follicular epithe lia.Results:The positive expression rates of MMP-2 and TIMP-2 in P TC were 76.8 %(43/56),and in the adjacent follicular epithelia to cancerous tiss ue were 33.9 %(19/56) and 32.1 %(18/56).The expression of MMP-2 in PTC was sign ificantly higher than those in the adjacent follicular epithelia.The expression of MMP-2 and TIMP-2 were not correlated with size of tumour.The expression of MMP-2 and TIMP-2 were correlated to the degree of the infiltration and lymph n ode metastasis in PTC.Conclusion:The expression of MMP-2 and TIMP-2 were closely cor related to the degree of infiltration and lymph node metastasis in PTC,which may serve as one of the parameters for determing biological behavior and prognosis of PTC.
出处
《肿瘤研究与临床》
CAS
2003年第5期297-299,共3页
Cancer Research and Clinic
