摘要
谷氨酸的兴奋毒性是造成视网膜神经节细胞损伤和死亡的主要因素之一,而谷氨酸转运体对维持细胞外谷氨酸水平起重要作用。GLAST是表达在Muller细胞膜上的一种重要的谷氨酸转运体,其在分子和蛋白质水平上的调节方式可能为酶底物—诱导的负反馈调节。
The excitatory neurotoxicity of glutamate is one of the main factors causing damage and death of retinal ganglion cells. Gluta-mate transporters are ultimately responsible for maintaining the appropriate extracellular glutamate concentration. GLAST is a major glutamate transporter expressed on the membrane of Muller cells and its modulation at the molecular and protein level may be a substrate-induced feedback regulation.
出处
《国际眼科杂志》
CAS
2003年第3期56-58,共3页
International Eye Science
