摘要
目的 研制阿莫西林缓释片 ,并对其体外释放度进行了考察。方法 以聚乙二醇 6 0 0 0为固体分散体载体 ,先将阿莫西林制备成固体分散体 ,增加阿莫西林在水中的溶出度 ,再以羟丙甲基纤维素为骨架材料 ,以水为粘合剂 ,采用湿法制粒压片 ,制备阿莫西林缓释片 ,并进行体外释放度试验。结果 该片在 1、2、3、6和 8h体外释放度控制在 30 %～ 4 5 %、4 5 %～ 6 5 %、6 0 %～ 80 %、75 %～ 95 %和 90 %以上 ,药物的体外释放模式符合 Highuchi方程。结论 研制缓释片的缓释效果良好。
Objective Amoxicillin sustained-release tablets were prepared and its in vitro dissolution was investigated. Method Using polyethylene glycol 6000 as solid dispersions carrier, the amoxicillin solid dispersions were prepared, and the dissolution of amoxicillin accelerated in the water. With hydroxypropylmethylcellulose as matrix material and water as adhesive, amoxicillin sustained-release tablets were prepared by using granulation method. The in vitro dissolution rates of the tablets were determined. Results The dissolution rate could be controlled in 30%～45%, 45%～65%, 60%～80%, 75%～95% and 90% at 1, 2, 3, 6 and 8h, respectively, the drug dissolution pattern was in accordance with Highuchi equation. Conclusion Sustained-release tablets had an expected sustained-release properties.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2003年第9期534-536,共3页
Chinese Journal of Antibiotics
关键词
阿莫西林
固体分散体
缓释片
体外释放度
Amoxicillin
Sustained-release tablets
Solid dispersions
In vitro release
