摘要
目的 :探讨非清髓异基因外周造血干细胞移植 (NAST)治疗老年重型再生障碍性贫血 (SAA)的方法及疗效。方法 :采用非清髓预处理的异基因外周造血干细胞移植治疗老年 SAA患者1例。供受者 HL A配型及红细胞 ABO血型完全相合。预处理方案主要由环胞霉素 A(Cs A)、抗淋巴细胞球蛋白 (ATG)和环磷酰胺组成。用环胞霉素 A和霉酚双酯 (MMF)预防移植物抗宿主病(GVHD)。采用 STR- PCR定量方法检测供者细胞植入情况。结果 :该例老年 SAA患者顺利度过移植后造血抑制期 ,于移植后第 8天外周血 WBC升至 0 .8× 10 9/ L,第 14天血象三系恢复 ,于移植后第 14天、30天、90天及 180天时检测供者细胞植入率均为完全植入。患者未出现移植物抗宿主病 ,现己无病存活 31个月。结论 :非清髓异基因外周造血干细胞移植简便安全 ,并发症少 ,疗效好 ,为老年
Objective:To investigate the use of nonmyeloablative allogenic peripheral blood stem cells transplantation(NAST)for severe aplastic anemia in older patients.Methods:One older patients of severe aplastic anemia with HLA identical siblings were received NAST using nonmyeloablative conditioning regimen.The engrefted donor cell were indentified by means of STR PCR 。Results:The older patients were engrafted of full donor cell.Hematopoiesis recovered rapidly,WBC recovered to 0.8×10 9/L on the 8 d.The cases did not develop GVHD.Conclusion:NAST is much safer and more effective approach and with less complications.It may represent a new approch in the treatment of older patients with severe aplastic anemia.
出处
《白血病．淋巴瘤》
CAS
2003年第4期209-211,共3页
Journal of Leukemia & Lymphoma
基金
全军"十五"重点课题资助项目 ( 0 2 10 3 0 )
关键词
非清髓异基因外周造血干细胞移植
老年
重型再生障碍性贫血
Nonmyeloablative allogenic peripheral blood tem cells transplantation
Older patients
Severe aplastic anemia
