摘要
[目的]观察肝苏颗粒治疗代偿期乙型肝炎肝硬化疗效。[方法]使用随机平行对照方法,将150例住院及门诊患者按就诊顺序编号分为两组。对照组75例护肝片,1.44g/次,3次/d,口服;复方益肝灵,1.28g/次,3次/d,口服。治疗组75肝苏颗粒,20g/次,早晚口服。两组连续治疗30d为1疗程。观测临床症状、脾厚、PVID、HBV-M、HBV-DNA、不良反应。连续治疗2疗程(60d),判定疗效。[结果]治疗组显效49例,有效15例,无效11例,总有效率85.33%。对照组显效20例,有效24例,无效31例,总有效率58.67%。临床疗效治疗组优于对照组(P<0.01)。B超指标治疗组优于对照组(P<0.05)。治疗组阴转24例,阴转率57.10%,对照组阴转13例,阴转率32.50%,治疗组优于对照组(P<0.05)。两组血清HBV-DNA水平均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]肝苏颗粒治疗代偿期乙型肝炎肝硬化效果显著,值得推广使用。
[Objective]Observation of Gansu granule in the treatment of compensated cirrhosis of hepatitis B.[Methods]Using randomized controlled methods,150 cases of inpatients and outpatients were randomly divided into two groups of numbers. A control group of 75 cases of liver protecting tablet,1.44g/,3 /d,oral+ compound Yigan,1.28g/,3 /d,oral. The treatment group of 75 liver Sue particles,20g/,sooner or later oral. Two sets of continuous treatment with 30d for 1 courses. Observation of clinical symptoms,B ultrasound,HBV-M index,HBV-DNA level changes,adverse reaction. Continuous treatment of 2 courses(60d),curative effect. 49 cases of group therapy[Results],15 cases were effective,11 cases ineffective,the total efficiency of85.33%. 20 cases of control group,24 cases effective,31 cases ineffective,the total efficiency of 58.67%. The clinical effect of the treatment group than in control group(P< 0.01). Treatment group was better than control group B ultrasound index(P< 0.05). Treatment group were negative in 24 cases,negative conversion rate was 57.10%,control group 13 cases were negative,negative conversion rate is 32.50%,the treatment group than the control group(P< 0.05). Serum level of HBV-DNA in two group were improved(P< 0.05),the treatment group was better than the control group(P< 0.05).[Conclusion]Gansu granule in the treatment of compensated cirrhosis of hepatitis B effect is significant,worthy of popularization.
出处
《实用中医内科杂志》
2013年第7S期74-76,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
肝硬化
乙型肝炎
代偿期
肝苏颗粒
护肝片
益肝灵
随机平行对照研究
Liver cirrhosis
Hepatitis B
Compensatory period
Gansu granule
Liver slices
Silymarin
Chinese medicine therapy
Randomized parallel controlled study
