摘要
目的探究长效生长抑素类似物结合神经内镜下手术治疗生长激素大腺瘤的临床效果。方法以98例生长激素大腺瘤患者为研究对象,行长效生长抑素类似物结合神经内镜下手术治疗的患者作为观察组,单纯进行手术治疗的患者作为对照组。调查患者的相关资料、临床特征,统计患者术后治疗效果以及患者手术前后各项指标变化。结果观察组患者术后GH谷值为(15. 3±12. 1) ng/L,TG水平为(1. 3±0. 7) mmol/L,LDL水平为(2. 2±0. 6) mmol/L,HDL水平为(1. 3±0. 2) mmol/L,ACTH水平为(25. 4±20. 6) pg/ml,与观察组患者术前指标相比较,差异具有统计学意义(t=2. 642、2. 037、2. 142、2. 204、2. 137,P均<0. 05);对照组患者术后GH谷值为(26. 7±20. 4) ng/L、TG水平为(1. 5±0. 8)mmol/L、TSH水平为(1. 4±1. 2) m U/L、ACTH水平为(24. 3±22. 1) pg/ml,与术前比较,差异具有统计学意义(t=2. 356、2. 144、2. 286、2. 414,P均<0. 05); 2组患者术后GH谷值变化差异具有统计学意义(t=2. 086,P <0. 05)。观察组患者肿瘤全切率为72. 73%、对照组患者肿瘤全切率为53. 70%。观察组患者术后GH得到缓解的患者占81. 82%、对照组患者为57. 41%,差异具有统计学意义(P <0. 05)。结论采用长效生长抑素类似物结合神经内镜下手术能够有效抑制患者体内GH水平,提高患者生长激素大腺瘤的全切率,改善患者由于生长激素大腺瘤而出现的糖、脂代谢紊乱情况。
Objective To explore the effect of long-acting somatostatin analogues combined with neuroendoscopy in patients with growth hormone adenoma.Methods A retrospective analysis of 98 patients from December 2014 to December 2016 in our hospital for the treatment of growth hormone adenoma patients with 98 patients with long-acting somatostatin analogues combined with neuroendoscopic treatment of patients as the observation group,Patients who underwent surgery were treated as a control group to investigate the patient’s clinical data.Statistics of patients with postoperative treatment and patients before and after surgery changes in the indicators.Results The level of GH was(15.3±12.1)ng/L,the level of TG was(1.3±0.7)mmol/L,the level of LDL was(2.2±0.6)mmol/L,the level of HDL was(1.3±0.2)mmol/L,the ACTH level was(25.4±20.6)pg/ml(t=2.642,2.037,2.142,2.204,2.137,P<0.05).The level of GH was(26.7±20.4)ng/L,TG level was(1.5±0.8)mmol/L,TSH level was(1.4±1.2)m U/Land AGTH level was(24.3±22.1)pg/ml,the difference was statistically significant(t=2.356,2.144,2.286,2.414,P<0.05).The difference of GH value between the two groups was statistically significant(t=2.086,P<0.05).The total tumor resection rate was 72.73%in the observation group and 53.70%in the control group.The patients in the observation group had the same effect(P<0.05).Conclusion Long-acting somatostatin analogues combined with neuroendoscopy can effectively inhibit the GH levels in patients,and the difference is statistically significant(P<0.05),and the difference between the two groups is 81.82%,Increase the patient’s growth hormone large adenoma of the total rate,can improve the patient due to growth hormone Large adenoma and the emergence of sugar,lipid metabolism disorders.
作者
魏建辉
田亚楠
张亚召
WEI Jianhui;TIAN Ya’nan;ZHANG Yazhao(Harrison International Peace Hospital,Hengshui,053000)
出处
《实用癌症杂志》
2019年第4期572-575,共4页
The Practical Journal of Cancer
