摘要
目的研究右美托咪定在宫颈癌、子宫内膜癌患者开腹手术全麻中的作用及对麻醉恢复情况的影响。方法将70例接受全麻开腹手术的宫颈癌或子宫内膜癌患者随机分为观察组和对照组,各35例。观察组患者术中给予右美托咪定持续静脉泵注至手术结束前30 min;对照组则以相同方式静脉泵注0.9%的生理盐水。记录观察患者各时间段MAP、HR、Sp O2、NI及Ramsay镇静评分变化情况;记录患者术后拔管时间、呼吸恢复时间、呼唤睁眼时间、定向力恢复时间及住院时间;同时记录2组患者围术期不良反应发生情况。结果观察组患者T2、T3、T4、T5MAP及HR均显著低于对照组(P<0.01);在T2、T3、T4时NI及Ramsay镇静评分均显著优于对照组(P<0.01);整个过程中2组患者Sp O2无明显差别(P>0.05)。2组患者术后恢复时间无统计学差异(P>0.05)。观察组患者恶心呕吐、躁动、拔管期呛咳及恢复期追加芬太尼等不良反应发生率均显著低于对照组(P<0.05)。结论右美托咪定应用于宫颈癌、子宫内膜癌患者开腹手术全麻中可保障围术期血流动力学稳定,显著降低不良反应发生率,且无呼吸抑制作用,不延长患者术后恢复时间。
Objective To observe the effect of dexmedetomidine in general anesthesia in abdominal surgery for cervical cancer and endometrial cancer and its recovery. Methods 70 patients with cervical cancer or endometrial cancer treated with abdominal surgery were divided into the observation group and the control group,each with 35 cases. The observation group were given dexmedetomidine in general anesthesia in abdominal surgery,while the control group were given 0. 9% intravenous saline.MAP、HR、Sp O2、NI and Ramsay scores were observed,postoperative extubation time,breathing recovery time,eye opening time,orientation recovery time,and hospitalization time were recorded. Adverse reactions of the 2 groups were compared. Results The MAP and HR of the observation group were significantly lower than those of the control group at T2、T3、T4、T5( P < 0. 01); the NI and Ramsay scores of the observation group were significantly higher than those of the control group at T2、T3、T4( P < 0. 01);There had no significant difference in Sp O2 between the 2 groups( P > 0. 05). There had no significant difference in postoperative recovery time between the 2 groups( P > 0. 05). The incidence of adverse reactions of the observation group was significantly lower( P < 0. 05). Conclusion The application of dexmedetomidine in general anesthesia in abdominal surgery for cervical cancer and endometrial cancer can effectively diminish the fluctuation of hemodynamics,reduce the incidence of adverse reactions without respiratory inhibition and prolong of recovery time.
出处
《实用癌症杂志》
2015年第10期1539-1541,1545,共4页
The Practical Journal of Cancer
关键词
右美托咪定
妇科肿瘤
全麻
效果
Dexmedetomidine
Gynecologic oncology
General anesthesia
Effect
