摘要
目的探讨DKK-1、GSK-3β、PGSK-3β在宫颈鳞癌组织中的表达及与其发生发展、临床病理特征的关系。方法收集病理组织标本:包括慢性宫颈炎25例,宫颈上皮内瘤变29例,宫颈鳞癌41例,采用免疫组织化学染色法分别检测其中DKK-1、GSK-3β、PGSK-3β的表达情况。结果慢性宫颈炎、宫颈上皮内瘤变组织中DKK-1阳性表达率均明显高于宫颈鳞癌(P<0.05)。慢性宫颈炎组织中GSK-3β阳性表达率明显高于宫颈癌组织(P<0.05),而PGSK-3β阳性表达率低于宫颈癌组织(P<0.05);DKK-1、PGSK-3β阳性表达与宫颈鳞癌组织分化、FIGO临床分期及有无淋巴结转移显著相关(P<0.05);PGSK-3β蛋白表达量CINⅠ、CINⅡ~Ⅲ及宫颈鳞癌组织明显高于慢性宫颈炎组织(P<0.05);CINⅠ中PGSK-3β蛋白表达量明显高于宫颈癌组织(P<0.05)。结论 DKK-1、GSK-3β、PGSK-3β表达与宫颈鳞癌的发生、发展密切相关。
Objective To investigate the expression of DKK-1,GSK-3βand PGSK-3βin squamous cell carcinoma of the cervix( SCC) ,and its relationship with the development and clinicopathological features of SCC .Methods 25 patients with chro-nic cervicitis,29 patients with CIN and 41 patients with SCC were selected .The expression of DKK-1,GSK-3β,PGSK-3βwere de-tected by immunohistochemistry technique .Results Expression rates of DKK-1in chronic cervicitis and CIN were significantly higher than that of the SCC(P<0.05);expression rate of GSK-3βin chronic cervicitis was significantly higher than that of the SCC(P<0.05);expression rate of PGSK-3βin chronic cervicitis was significantly lower than that of the SCC (P<0.05);posi-tive expression rates of DKK-1and PGSK-3βwere related with tissue differentiation ,FIGO clinical stage and lymph node metasta-sis ( P<0.05);expression rates of PGSK-3βin CIN Ⅰ,CIN Ⅱ~Ⅲand SCC tissues were significantly higher than that of the chronic cervicitis(P<0.05);PGSK-3βexpression in CIN I was significantly higher than that of SCC tissue (P<0.05).Conclu-sion There is a close correlation between DKK-1,GSK-3β,PGSK-3βexpression and the development of SCC .
出处
《实用癌症杂志》
2014年第8期908-911,共4页
The Practical Journal of Cancer
