摘要
自噬是溶酶体降解途径之一,在众多真核生物细胞生理过程中发挥着重要作用。近年来,人们发现自噬对肿瘤的发生、发展过程同样具有显著的影响。自噬对肿瘤的影响具有两面性:一方面,自噬能够避免细胞遭受氧化胁迫、持续性炎症及DNA损伤的积累等,从而抑制癌症的发生;另一方面,自噬又为肿瘤细胞提供生长所需的代谢中间产物,维持肿瘤细胞内环境的稳定,进而促进肿瘤的发展。因此,自噬在肿瘤的治疗过程中同样具有正、反两方面的影响,诱导自噬:一方面能够减少放射治疗及化学治疗引起的细胞DNA损伤和染色体突变的积累,从而防止肿瘤的加剧;另一方面,肿瘤细胞又能够依赖自噬来缓解药物和射线产生的压力,从而有利于自身的存活。
Autophagy is one of the lysosomal degradation pathways,which plays critical roles in multiple physiological processes in eukaryotes.In recent years,it has been believed that autophagy is tightly involved in tumorigenesis and development.The effects of autophagy on cancer are controversial.Autophagy prevents cells from oxidative stress,persistent inflammation,and DNA damage accumulation during carcinogenesis,and eventually inhibits the development of cancer.However,autophagy also provides growth metabolites needed for tumour cells,and maintains the balance of the intracellular environment,thus promoting carcinogenesis.Autophagy also has double-edged effects on cancer therapy:on one hand,induction of autophagy prevents the accumulation of DNA damages and mutations induced by chemotherapy or radiotherapy,and then inhibits cancer progression; on the other hand,autophagy is required for tumor cells to relieve drug and irradiation therapeutic pressures,and potentially contributes to the survival of tumor cells.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2015年第11期70-76,共7页
China Biotechnology
基金
国家自然科学基金(31201051)
上海市自然科学基金(12ZR1433100
12ZR1433000)
国家"973"计划(2015CB964800)资助项目
关键词
自噬
癌症发生
肿瘤治疗
Autophagy
Tumorigenesis
Cancer therapy
