摘要
2006年,首次报道在体外简单的转录因子就可以使体细胞重编程为多能性细胞。自从这项技术诞生以来,人们为改善诱导多能干细胞(iPSCs)技术做出了巨大努力,发展各种方法用于将重编程因子导入体细胞制备诱导多能干细胞(iPSCs)。诱导多能干细胞(iPSCs)技术彻底改变了人类对疾病发病机制的探索和药物开发的进程。本文简述了诱导多能干细胞的来源及诱导策略、近年来iPSCs在疾病建模、药物研发、再生医学等方面的应用,同时探讨了该技术当前存在的问题,并对未来进行了展望。
In 2006,it was first reported that in vitro transcription factors could reprogram somatic cells into pluripotent cells.Great efforts have been made to improve the technology of induced pluripotent stem cells(iPSCs)since then,and various methods developed to transfer reprogramming factors into somatic cells to generate iPSCs.The iPSCs technology completely changed the exploration of the pathogenesis of disease and the process of drug development.In this article,we briefly reviewthe inducement strategies of iPSCs,the application of iPSCs in disease modeling,drug discovery and regenerative medicine.The future and problem of i PSC were also discussed.
作者
董明清
邢书娟
梁晓庆
周宝珍
张敏利
DONG Ming-qing;XING Shu-juan;LIANG Xiao-qing;ZHOU Bao-zhen;ZHANG Min-li(Xi'an International University,Xi'an,Shaanxi,710077,China)
出处
《现代生物医学进展》
CAS
2019年第13期2596-2600,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81571822,81570054,81372129)
西安外事学院博士科研启动基金项目(XAIU2018070106)
