摘要
目的探讨长脉冲1064nm激光与抗组胺药物治疗慢性湿疹的疗效与安全性。方法选择2017年1—12月门诊收治的慢性湿疹患者226例,采用数字表随机法分为两组,每组各113例。对照组口服第2代抗组胺药物,外用1%氢化考的松乳膏。观察组采用长脉冲1064nm ND:YAG激光治疗,外用1%氢化考的松乳膏,1次/周,共治疗4周,疗程结束后,评价临床疗效及不良反应。治愈患者随访8周,记录复发情况。结果 4周疗程结束后,观察组症状积分为(2.97±0.14)分,明显低于对照组的(5.67±0.83)分,其差异有统计学意义(P<0.05)。观察组总有效率为78.76%,明显高于对照组的54.87%,其差异有统计学意义(P<0.05)。对照组复发率为37.93%,明显高于观察组的8.51%,其差异有统计学意义(χ~2=10.247,P<0.001)。观察组中无一例因激光照射发生色素沉着、紫癜、色素减退等。结论采用长脉冲1064nm ND∶YAG激光治疗慢性湿疹,疗效与安全性均优于抗组胺药物。
Objective To explore the efficacy and safety of long pulse 1064 nm laser and antihistamine in the treatment of chronic eczema. Methods From January to December 2017, 226 patients with chronic eczema in outpatient treatment were involved in the study. Patients were divided into two groups based on a random number table, with 113 cases in each group. The second generation of antihistamines was taken orally, and 1% hydrocortisone cream was applied for external use in the control group. Long pulse 1064 nm ND:YAG laser was performed, and 1% hydrocortisone cream was applied for external use in the observation group. The treatment course was once a week, for a total of 4 weeks. After treatment, the clinical efficacy and adverse reactions were evaluated. Treated patients were followed up for 8 weeks and recurrences were recorded. Results The score of symptoms in the observation group was(2.97±0.14), significantly lower than that of the control group(5.67±0.83). The difference was statistically significant(P<0.05). The total effectiveness rate of the observation group was 78.76%, significantly higher than that of the control group(54.87%). The difference was statistically significant(P<0.05). The recurrence rate in the control group was 37.93%, significantly higher than that of the observation group(8.51%). The difference was statistically significant(χ~2=10.247, P<0.001). No pigmentation, purpura, or hypopigmentation occurred in the observation group. Conclusion The efficacy and safety of long pulse 1064 nm ND: YAG laser in the treatment of chronic eczema was better than that of antihistamines.
作者
贝宏
罗文霞
杨万英
BEI Hong;LUO Wen-xia;YANG Wan-ying(Department of Dermatology and Venereal Disease,People's Hospital of Longhua District of Shenzhen,Shenzhen 518109,China)
出处
《中国美容整形外科杂志》
CAS
2019年第3期162-164,194,共4页
Chinese Journal of Aesthetic and Plastic Surgery
