摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的神经退行性疾病,其发病机制涉及环境、遗传、衰老、饮食和基础疾病等多种因素。同时AD的复杂致病因素导致其确诊延迟、药物研发困难、治愈率低、护理成本高等诸多社会及经济问题。本文以脑能量代谢异常为主线,梳理了AD疾病进程与其风险疾病如代谢性疾病、慢性炎性疾病和心血管疾病的关系,分析了脑能量代谢信号/通路异常在风险疾病向AD病变衍变过程中的作用角色和地位。指出防治风险疾病演变、改善异常能量代谢信号可能是防治AD的有效策略之一。
Alzheimer.s disease(AD) is a complex neurodegenerative disease. Its pathogenesis involves many factors such as environment, heredity, aging, diet, personal preference and underlying diseases. And the complex pathogenic factors of AD lead to many social and economic problems such as delayed diagnosis, difficulty of drug research and development,low cure rate and high cost of care. In this paper, the relationship between AD disease progression and its risky diseases such as metabolic diseases, chronic inflammatory diseases and cardiovascular diseases was analyzed based on energy metabolism abnormalities. The role of energy metabolism signal/path abnormality activity in the course of risk disease to AD disease was analyzed. Finally, it is suggested that the prevention and treatment of risk disease evolution and adjustment of abnormal energy metabolism signals may be effective strategies for the treatment of AD.
作者
文雯
高丽娟
魏江平
秦莉霞
文跃强
徐世军
Wen Wen;Gao Lijuan;Wei Jiangping;Qin Lixia;Wen Yueqiang;Xu Shijun(School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Institute of Meterial Medica Integration and Transformation for Brain Disorders,Chengdu University ofTraditional Chinese Medicine, Chengdu 611137, China;School of Basic Medicine,Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2018年第12期2145-2149,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委重点基金项目(81430100):解毒通络治法调整脑内微环境改善AD失连接的临床基础研究
负责人:张占军
关键词
阿尔茨海默症
风险疾病
能量代谢
线粒体
Alzheimer.s disease
risky diseases
energy metabolism
mitochondria
