摘要
目的探讨丹红注射液对胫骨骨折术后患者血清骨性标志物及愈合时间的影响。方法收集武警浙江省总队嘉兴医院军人病区收治胫骨骨折患者52例,随机分为对照组和实验组,每组26例,所有患者均行髓内钉固定手术治疗。术后,在常规治疗基础上,对照组给予注射用骨肽50 mg,溶于250 m L 0.9%氯化钠溶液中,1次/天静滴;实验组给予丹红注射液20 m L,溶于250 m L0.9%氯化钠溶液中,1次/天静滴。14 d为1个疗程,2组患者均治疗2个疗程。治疗结束后,对所有患者的血清骨钙素(bone Glaprotein,BGP)、I型前胶原羧基端肽(carboxyterminal propeptide of type I procollagen,PICP)、骨源性碱性磷酸酶(bone alkaline phosphatase,BALP)及骨折愈合时间进行检测。结果与对照组治疗后比较,实验组患者血清BGP、PICP水平较高(P<0.05);实验组患者的血清BALP水平较高(P<0.05);实验组患者的平均骨折愈合时间较短(P<0.05)。结论丹红注射液能够显著升高胫骨骨折术后患者血清BGP、PICP以及BALP水平,缩短骨折愈合时间。
Objective To analyse effect of Danhong injection on serum levels of bone markers and healing time in postoperative patients with tibial fractures.Methods 52 patients who were diagnosed with tibial fractures in our hospital were collected and randomly divided into control group and experimental group.All patients were treated with intramedullary nailing.After the operation, on the basis of routine treatment, patients in control group were treated with ossotide injection 50 mg, dissolved in 250 mL 0.9% sodium chloride solution, one times per day.Patients in experimental group was treated with Danhong injection 20 mL, dissolved in 250 mL 0.9% sodium chloride solution, one times per day.14 days for one period of treatment, two groups were treated for two cycles.After the treatment,the serum levels of bone Gla-protein (BGP), carboxyterminal propeptide of typeⅠprocollagen (PICP), bone alkaline phosphatase (BALP) and the racture healing time were detected in all patients.Results Compared with control group post-treatment, the serum BGP and PICP levels were higher in experimental group (P<0.05);the serum BALP level was higher in experimental group (P<0.05); the average fracture healing time of the patients in experimental group was shorter (P<0.05).Conclusion Danhong injection can significantly increase the serum BGP, PICP and BALP level in postoperative patients with tibial fractures, shorten fracture healing time.
出处
《中国生化药物杂志》
CAS
2015年第10期41-43,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
丹红注射液
胫骨骨折术后
骨性标志物
愈合时间
Danhong injection
postoperative tibial fractures
bone marker
healing time
