摘要
目的探讨帕米膦酸二钠治疗骨转移癌患者的疗效。方法选取安阳市肿瘤医院骨转移癌患者50例,根据用药不同分为对照组和实验组,每组各25例,对照组按化疗方案给予化疗,实验组在对照组基础上给予帕米膦酸二钠45 mg+0.9%氯化钠溶液500 m L,静脉滴注。治疗后对2组患者的止痛维持时间、患者疼痛分级以及血清Ⅰ型胶原交联氨基末端肽(N-telopeptide of typeⅠcollagen,NTx)水平进行检测。结果与对照组患者相比,实验组止痛持续时间较长(P<0.05),疼痛水平总体较低,NTx水平较低(P<0.05)。结论帕米膦酸二钠能够明显抑制骨转移癌患者的骨痛程度,降低血清NTx水平。
Objective To investigate the efficacy of disodium pamidronate in treatment of bone metastasis cancer .Methods 50 cases of bone metastasis cancer were divided into control group and experimental group according to different medication, 25 cases in each group.Control group was treated by chemotherapy, experimental group was treated on the basis of control group with disodium pamidronate 45 mg+0.9%sodium chloride solution 500 mL, intravenous drip.Pain maintenance time, patient pain grading and serum NTx levels were compared after treatment.ResuIts Compared with control group,pain maintenance time of experimental group was longer(P <0.05),pain level overall score was lower,NTx was lower(P <0.05). ConcIusion Disodium pamidronate can inhibit bone metastasis cancer patients with the degree of pain, reduce the levels of serum NTx.
出处
《中国生化药物杂志》
CAS
2015年第8期131-133,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
帕米膦酸二钠
骨转移癌
骨痛
NTX
disodium pamidronate
bone metastasis cancer
bone pain
NTx
