摘要
目的探讨沙丁胺醇气雾剂联合硫酸镁对小儿哮喘IL-2、IL-4、IL-5、IFN-γ及T淋巴细胞亚群的影响。方法选取已确诊为哮喘的患儿38例,采用随机数字表法将患者随机分为实验组和对照组,对照组予临床常规方法治疗,实验组采用沙丁胺醇气雾剂联合硫酸镁治疗,疗程1周。观察2组患者IL-2、IL-4、IL-5、IFN-γ、T淋巴细胞亚群、血压、心率、呼吸和临床疗效。结果与对照组相比,实验组患者血清IL-2、IFN-γ水平较高(P<0.05),IL-4、IL-5水平较低(P<0.05);实验组CD3+、CD4+、CD4+/CD8+水平较高(P<0.05),血清CD8+较低(P<0.05),实验组总有效率较高(P<0.05)。结论沙丁胺醇气雾剂联合硫酸镁能有效调节哮喘患儿T淋巴细胞亚群比例和细胞因子水平,提高免疫力,改善临床症状。
Objective To investigate the effect of salbutamol aerosol combined with magnesium sulfate on IL-2,IL-4,IL-5,IFN-γ and T lymphocyte subsets in pediatric asthma patients. Methods 38 pediatric asthma patients were selected and randomly divided into control group and experimental group. Control group was treated by clinical routine method. Experimental group was treated by salbutamol aerosol combined with magnesium sulfate. The IL-2,IL-4,IL-5,IFN-γ,T lymphocyte subsets,blood pressure,heart rate,respiratory and clinical effects were observed and compared. Results Compared with control group,the serum levels of IL-2 and IFN-γ were higher( P < 0. 05). The IL-5,IL-4 level were lower( P <0. 05). The CD3+,CD4+,CD4+/ CD8+level were higher( P < 0. 05). The serum CD8+were lower( P < 0. 05). The total efficiency were higher( P <0. 05). Conclusion Salbutamol aerosol combined with magnesium sulfate can effectively regulate T lymphocyte subsets proportion and cytokine levels in asthmatic children,enhance immunity,and improve the clinical symptoms.
出处
《中国生化药物杂志》
CAS
2015年第8期110-112,115,共4页
Chinese Journal of Biochemical Pharmaceutics
