摘要
目的探究黄连素对老年慢性萎缩性胃炎患者血清胃蛋白酶以及胃泌素的表达的影响,探讨黄连素治疗老年慢性萎缩性胃炎机制及其临床意义。方法选取河源市人民医院消化内科收治的老年慢性萎缩性胃炎患者83例,随机分为2组,其中对照组40例,Hp阴性患者给予奥美拉唑治疗;Hp阳性患者给予克拉霉素+阿莫西林+奥美拉唑三联疗法消除Hp,阿莫西林过敏患者替换为甲硝唑,7天为1个疗程,治疗2个疗程;实验组43例,在常规治疗的基础上加用复方黄连素片,7天为1个疗程,治疗2个疗程。比较治疗前后患者血清胃蛋白酶原、胃泌素、HP转阴率、总有效率以及不良反应情况。结果治疗前2组患者PGI、PGⅡ水平比较差异无统计学;经治疗后,2组患者血清PGI、PGR水平均较治疗前有所上升(P<0.05),PGⅡ无明显变化;与对照组比较,实验组PGI、PGR水平上升较显著,差异具有统计学意义(P<0.05);治疗后2组胃泌素水平均有所上升,与对照组比较,实验组胃泌素明显改善,差异有统计学意义(P<0.05);2组的胃HP阳性率分别为70.0%、72.1%,2组比较差异无统计学意义;经治疗后,与对照组胃HP转阴率(57.14%)比较,实验组胃HP转阴率(70.96%)显著升高,差异有统计学意义(P<0.05);治疗后2组患者病情均有所改善,与对照组比较,实验组有效率显著较高,差异有统计学意义(P<0.05)。结论黄连素具有较好的抑菌、杀菌作用,能够干预老年慢性萎缩性胃炎患者血清胃蛋白酶原及胃泌素水平,对临床具有指导意义。
Objective To explore the effect of berberine on expression of serum pepsinogen and gastrin in elderly patients with chronic atrophic gastritis,and its mechanism and clinical value. Methods 83 elderly patients with chronic atrophic gastritis were selected from heyuan people's hospital,randomly divided into 2 groups,40 patients in control group. Hp negative patients were given omeprazole treatment; Hp positive patients were given clarithromycin,amoxicillin,omeprazole triple therapy to eliminate Hp,patients who were allergic to amoxicillin replaced metronidazole,7 days for a course of treatment,two courses of treatment; 43 cases in experimental group,on the basis of conventional therapy plus Compound Berberine Tablets,7days for a course,two courses of treatment. Serum pepsinogen,gastrin,Hp negative rate,the total effective rate and adverse reaction were compared before and after treatment. Results PGI and PG II levels in two groups before treatment,there were no significant differences; after treatment,serum PGI,PGR in two groups were lower than before treatment(P < 0. 05),PG II had no obvious change; compared with control group,PGI,PGR of experimental group increased significantly(P < 0. 05); after treatment,gastrin level in two groups all increased,compared with control group,the experimental group gastrin significantly improved,the difference was statistically significant(P < 0. 05); the positive rate of gastric HP in two groups were 70. 0%,72. 1%,but two groups had no statistical significance; after treatment,control group of gastric HP negative rate(57. 14%),the gastric HP negative rate in experimental group(70. 96%) significantly increased,with statistically significant difference(P < 0. 05); two groups after treatment were improved,compared with control group,experimental group had significantly higher efficiency,the difference was statistically significant(P <0. 05). Conclusion Berberine has good antibacterial,bactericidal effect,can intervene in serum pepsinogen and gastrin level in elderly patients with ch
出处
《中国生化药物杂志》
CAS
北大核心
2014年第8期139-141,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
河源市科技计划项目(2014-10)
河北省科技支撑计划项目
承德市科学技术研究与发展计划项目(20122170)
关键词
黄连素
老年萎缩性胃炎
胃蛋白酶原
胃泌素
berberine
elderly patients with chronic atrophic gastritis
pepsinogen
gastrin
