摘要
目的通过检测孕妇早期血清中解整合素-金属蛋白酶12-S(a disintegrin and metalloprotease 12,ADAM12-S)水平及变化趋势,探讨解整合素-金属蛋白酶12-S在孕妇早期异位妊娠诊断中的价值。方法选取黄冈市妇幼保健院就诊的早孕期妇女(孕5~10周)150例,其中正常妊娠102例,异位妊娠48例,留取其血清,利用时间分辨荧光免疫分析法检测血清中解整合素-金属蛋白酶12-S值。结果 102例正常妊娠组孕妇血清中ADAM12-S值随孕周呈线性稳定增长,相关系数r=0.9217(P<0.05);48例异位妊娠组孕妇血清中ADAM12-S值明显低于正常妊娠组且随孕周未呈线性稳定增长,相关系数r=0.2817;异位妊娠组各孕周的中位数倍数明显低于正常对照组,差异有统计学意义(P<0.05)。结论 ADAM12-S在早孕正常妊娠中数值稳定,而在异常妊娠中数值低,在孕妇早期异位妊娠诊断中具有重要价值。
Objective To determine the values and variation tendency of a disintegrin and metalloprotease 12-S(ADAM12-S)of early pregnancy, and discuss the value of ADAM12-S to the ectopic pregnancy in the first trimester.Methods 150 early pregnancy cases (from the 5th to 10th week of pregnancy)were selected in Huanggang Women &Children''s Healthcare Hospital.There were 102 cases of normal pregnancy,48 cases of ectopic pregnancy.The AutoDELFIA immunoassay platform was used to measure the value of ADAM12-S in the serum.Results Of the 102 normal pregnancies, the values of ADAM12-S in 5th-10th week of pregnancy linearly increase with gestationalage.The correlation coefficient was 0.9217 (P<0.05).While the values of ADAM12-S in the ectopic pregnancy group were significantly lower than the normal pregnancy group and not linearly increased with gestationalage.The correlation coefficient was 0.2817.There was statistically significant difference between the two groups (P<0.05).Conclusion The values of ADAM12-S is stable in the first trimester of normal pregnancy,while it is much more lower in abnormal pregnancy.ADAM12-S has great significance in the diagnosis of ectopic pregnancy of the first trimester.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第7期161-163,166,共4页
Chinese Journal of Biochemical Pharmaceutics
基金
山东省自然科学基金课题项目(ZR2009CL027)
济南市科技局科技明星计划课题项目(20100118)
山东省医学科学院医学基金课题项目(201023)
