摘要
目的对比不同梗死面积、不同神经功能缺损程度、不同预后的急性脑梗死(ACI)患者血清趋化素(Chemerin)、网膜素-1(Omentin-1)水平。方法选取108例ACI患者作为观察组,其中大面积脑梗死12例(梗死最大直径≥5 cm)、中面积脑梗死37例(梗死最大直径>3～5 cm)、小面积脑梗死40例(梗死最大直径1.5～3 cm)、腔隙性脑梗死19例(梗死最大直径<1.5 cm),神经功能缺损程度为重度19例(NIHSS评分>15分)、中度45例(15分≥NIHSS评分>5分)、轻度44例(NIHSS评分≤5分)。对ACI患者随访90 d,预后良好(mRS≤2分)83例和预后不良(mRS>2分)25例。另择100例非ACI患者作为对照组。采用酶联免疫吸附实验双抗体夹心法检测观察组发病<48 h、第7天及对照组入院当天血清Chemerin、Omentin-1水平,并对上述不同组间血清Chemerin、Omentin-1水平进行比较。Pearson相关分析观察组血清Chemerin、Omentin-1水平与NIHSS评分的关系。结果与对照组比较,观察组发病<48 h、第7天血清Chemerin水平均高(P均<0.01),血清Omentin-1水平均低(P均<0.01)。同时间ACI患者血清Chemerin水平比较,大面积脑梗死>中面积脑梗死>小面积脑梗死、腔隙性脑梗死,重度神经功能缺损程度>中度神经功能缺损程度>轻度神经功能缺损程度,P均<0.05;同时间ACI患者Omentin-1水平比较:大、中面积脑梗死<小面积脑梗死<腔隙性脑梗死,重度神经功能缺损程度<中度神经功能缺损程度<轻度神经功能缺损程度,P均<0.05。与同组发病<48 h比较,发病第7天不同脑梗死面积及不同神经功能缺损程度的脑梗死患者血清Chemerin水平降低、Omentin-1水平升高(P均<0.05)。ACI发病<48 h、第7天血清Chemerin水平与NIHSS评分呈正相关(r=0.806,P<0.01;r=0.749,P<0.01),血清Omentin-1水平与NIHSS评分呈负相关(r=-0.684,P<0.01;r=-0.588,P<0.01)。与预后良好组比较,ACI预后不良组患者血清Chemerin水平高,Omentin-1水平低(P均<0.05)。结论脑梗死面积大�
Objective To observe the changes of serum chemerin and omentin-1 levels in acute cerebral infarction(ACI)patients with different infarct sizes,degree of neurological deficit,and prognosis,and to explore the relationships of serum chemerin and omentin-1 levels with ACI.Methods Totally 108 patients with ACI were selected as the observation group,grouped by infarct size:12 patients with large area ACI(maximum diameter≥5 cm),37 patients with middle area ACI(5 cm>maximum diameter≥3 cm),40 patients with small area ACI(3 cm>maximum diameter≥1.5 cm),and 19 patients with lacunar infarction(maximum diameter<1.5 cm);grouped by neurological deficits:19 severe patients(NIHSS score>15),45 moderate patients(15≥NIHSS score>5),and 44 mild patients(NIHSS score≤5).All patients with ACI were followed up for 90 days,and the prognosis was good(mRS≤2)in 83 cases and poor prognosis(mRS>2)in 25 cases.Another 100 cases of non-ACI persons were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect and compare the serum levels of chemerin and omentin-1 in the observation group(within 48 h of the onset and at 7 d after ACI)and control group(on the day of admission).Pearson correlation analysis was used to analyze the correlation between the serum levels of chemerin and omentin-1 and NIHSS score in the observation group.Results Compared with the control group,the serum chemerin levels were higher at 48 h and 7 d after ACI,respectively,and serum omentin-1 levels were lower in the observation group(all P<0.01).At the same time,the serum Chemerin levels in ACI patients were in the following order:large area ACI>middle area ACI>small area ACI,lacunar infarction,severe>moderate>mild(all P<0.05);comparison in the omentin-1 levels:large and medium area ACI<small area ACI<lacunar infarction,severe<moderate<mild(all P<0.05).In the same group,the serum chemerin levels decreased and omentin-1 levels increased in ACI patients with different infarct area and different conditions compared with those within 48 h
作者
徐品丽
李文宝
冯大勇
姚恩生
王宏
XU Pinli;LI Wenbao;FENG Dayong;YAO Ensheng;WANG Hong(The First Affiliated Hospital of Shihezi University Medical College,Shihezi 832000,China)
出处
《山东医药》
CAS
2019年第9期15-18,共4页
Shandong Medical Journal
基金
石河子大学医学院第一附属医院院级科技计划项目(BS201705)
石河子大学校级科研项目(ZZZC201713A)
