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舌鳞状细胞癌组织Bmi1表达及意义

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摘要 目的观察舌鳞状细胞癌组织B细胞特异性莫洛尼白血病毒插入位点1(Bmi1)的表达情况,探讨其与患者临床病理特征的关系。方法选择舌鳞状细胞癌组织69份(观察组),同体癌旁正常组织20份(对照组)。采用免疫组化法检测两组Bmi1表达,并分析其与舌鳞状细胞癌患者临床病理特征的关系。结果观察组Bmi1阳性表达56例,阳性率为81.2%;对照组Bmi1阳性表达3例,阳性率为15.0%;两组阳性率比较,P<0.01。Bmi1阳性表达与舌鳞状细胞癌患者的性别、年龄、分化程度无关(P均>0.05),与浸润深度、淋巴结转移及术后复发转移有关(P均<0.05)。结论舌鳞状细胞癌组织中Bmi1蛋白表达升高,其表达变化可能参与了肿瘤的侵袭、转移,并有助于判断患者的预后。
作者 刘硕硕 陆宇
机构地区 泰州市第二人民医院
出处 《山东医药》 CAS 北大核心 2015年第48期80-82,共3页 Shandong Medical Journal
关键词 舌鳞状细胞癌 侵袭 转移 预后 B细胞特异性莫洛尼白血病毒插入位点1
分类号 R739.8 [医药卫生—肿瘤]
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参考文献16

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山东医药
2015年 第48期

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