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血管内皮生长因子靶向药物治疗难治性分化型甲状腺癌的研究进展 被引量：1

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摘要 分化型甲状腺癌(DTC)向难治性DTC转变与血管内皮生长因子(VEGF)通路有关,故癌组织中VEGF表达升高可作为预测难治性DTC患者预后的指标之一。研究抗VEGF通路的靶向药物对难治性DTC的治疗具有重要意义。基础研究药物中,舒尼替尼、凡德他尼等VEGF靶向药物具有抑制难治性DTC细胞增殖及活性的作用;临床研究药物中,索拉非尼、凡德他尼、兰伐替尼等VEGF靶向药物具有缓解DTC病情并延长无瘤生存时间的作用。
作者 肖雄 王新华 董占飞
机构地区 新疆医科大学附属肿瘤医院
出处 《山东医药》 CAS 北大核心 2015年第40期97-99,共3页 Shandong Medical Journal
关键词 甲状腺肿瘤 分化型 难治性 血管内皮生长因子 靶向治疗
分类号 R736.1 [医药卫生—肿瘤]
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参考文献20

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山东医药
2015年 第40期

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