摘要
目的:观察并比较癌痛应用阿片药物联合姑息性化疗与单纯应用阿片药物控制的效果。方法:选取2014年3月-2016年9月期间,于我院诊疗的中晚期癌症患者76例作为研究对象,所有患者经过NRS疼痛评分法测定,均存在中度或重度疼痛,采用随机分组法,将患者分为实验组及对照组,每组38例,实验组采用阿片药物联合姑息性化疗缓解癌痛,对照组则单独应用阿片药物缓解癌痛,观察并比较两组患者治疗后疼痛缓解情况、疼痛暴发情况、阿片药物应用剂量等。结果:实验组患者的疼痛评分、疼痛暴发次数、吗啡应用剂量明显少于对照组患者的疼痛评分、疼痛暴发次数、吗啡应用剂量,组间数据差异显著,P<0.05,有统计学意义;治疗前,两组患者的疼痛程度比较,组间数据未见显著差异,P>0.05,无统计学意义;治疗后,实验组患者的疼痛缓解程度明显优于对照组患者的疼痛缓解程度,组间数据差异显著,P<0.05,有统计学意义。结论:采用姑息性化疗联合阿片药物对癌痛的控制效果较好,患者的疼痛程度明显缓解,疼痛暴发频率明显减少,阿片药物应用剂量有所降低,是控制处于中晚期癌症且伴有癌痛症状较好治疗方法,值得临床推广应用。
Objective: to observe and compare the application of opioid drugs joint pain palliative chemotherapy and simple application of opioid drugs control effect. Method: choose 2014 during 3 month-in September 2016, 76 cases in our hospital diagnosis and treatment of locally advanced cancer patients as the research object, all of the patients after NRS pain score method, there are moderate or severe pain, using the randomized method, divided the patients into the experimental group and control group, each group of 38 cases of experimental group using opioid drugs combined palliative chemotherapy, pain relief in the control group separately in application of opioid drugs, pain relief to observe and compare the two groups after treatment in patients with pain relief, outbreaks of pain, opioid drug dose, etc. Results: the scores of pain, pain in patients with outbreaks, morphine dose markedly less than control group in patients with pain pain score, the number of outbreaks, morphine dose, data significant difference between groups, P < 0.05, there is statistical significance; Before the treatment, two groups of patients to compare pain degree, data no significant differences between groups, P > 0.05, no statistical significance; The degree of pain relief after treatment, the experimental group patients was better than control group in patients with the degree of pain relief, data significant difference between groups, P < 0.05, with statistical significance. Conclusion: with palliative chemotherapy in combination with opioid medications for pain control effect is better, level of pain in patients with apparent ease, outbreak frequency significantly reduced pain, opioid drug dose, is in the middle-late stage of cancer control and pain symptoms better treatments, worthy of clinical popularization and application.
出处
《中国妇幼健康研究》
2017年第S2期61-62,共2页
Chinese Journal of Woman and Child Health Research
