摘要
目的:探讨强化康复护理干预在齐拉西酮联合小剂量氯氮平治疗女性难治性精神分裂症中的应用价值。方法:选取2015年6月至2016年1月我院精神科收治的女性难治性精神分裂症患者80例作为研究对象。所有患者均应用齐拉西酮联合小剂量氯氮平进行治疗,采用随机数表法将患者分为护理组与对照组,每组患者40例,其中对照组患者治疗期间接受临床常规护理干预,护理组患者治疗期间则接受强化康复护理干预,比较两组患者干预后PANSS评分以及治疗后N-BPRS评分情况,并对比两组患者治疗效果以及不良反应、生活质量、治疗依从性、护理满意度情况。结果:治疗干预后护理组患者PANSS量表评分中G、N、P、T项目评分均明显低于对照组(P<0.05),并且护理组患者治疗干预后4、8、12周末时,N-BPRS评分均明显高于对照组(P<0.05),同时治疗总有效率统计结果显示,治疗8周时护理组治疗总有效率明显高于对照组,护理组患者不良反应发生率明显低于对照组(P<0.05);护理组患者生活质量评分明显优于对照组,并且治疗期间护理组患者治疗依从性、护理满意度明显高于对照组,P<0.05,具有统计学意义。结论:对应用齐拉西酮联合小剂量氯氮平治疗的女性难治性精神分裂症患者实施强化护理干预可有效改善患者精神分裂症临床症状,显著提升患者临床治疗效果,并且可提高患者治疗用药的依从性以及对护理的满意度,具有临床应用及推广价值。
Objective: To strengthen the rehabilitation nursing intervention in application of refractory spirit in ziprasidone combined with small dose of clozapine in the treatment of female schizophrenia. Methods: from June 2015 to January 2016 in our hospital psychiatric admitted female refractory schizophrenia patients 80 cases as the research object. All patients were treated with ziprasidone combined with small dose of clozapine treatment, using random number of patients were divided into nursing group and control group, 40 cases in each group, the control group patients treated during routine clinical nursing intervention during the nursing group patients received intensive rehabilitation nursing intervention, compared two groups of patients after the intervention of PANS S score and N-BPRS score after treatment, and compared the two groups of patients with treatment effect and adverse reactions, quality of life, treatment compliance, nursing satisfaction Results: the treatment group patients after nursing intervention PANSS scores of G, N, P, T scores were significantly lower than the control group(P<0.05), and nursing intervention 4,8,12 after the weekend, N-BPRS scores were significantly higher than the control group(P<0.05), the total efficiency of the treatment at the same time the statistics show that after 8 weeks of treatment and nursing treatment group total effective rate was significantly higher than the control group, nursing adverse reactions of patients was significantly lower than the control Group(P<0.05); quality of life in patients with nursing group was significantly better than the control group, and nursing care of patients during the treatment, treatment compliance, nursing satisfaction was significantly higher than the control group, P<0.05, has statistical significance. Conclusion: The application of ziprasidone combined with small dose of clozapine in the treatment of female patients with refractory schizophrenia intensive nursing intervention can effectively improve the clinical symptoms of
出处
《中国妇幼健康研究》
2017年第S1期413-414,共2页
Chinese Journal of Woman and Child Health Research
关键词
齐拉西酮
女性难治性精神分裂症
临床疗效
强化康复护理干预
ziprasidone
female refractory schizophrenia
clinical curative effect
strengthen the rehabilitation nursing intervention
