摘要
目的 评价帕尼培南/倍他米隆治疗老年严重院内感染的疗效和安全性。方法 老年院内感染患者78例,年龄73～95岁,随机分为帕尼培南/倍他米隆组42例,亚胺培南/西司他丁组36例,观察两组患者用药后下呼吸道和泌尿系统感染的临床疗效、细菌清除情况及不良反应。结果 帕尼培南/倍他米隆组、亚胺培南/西司他丁组的临床有效率分别为76.2％和69.4％,细菌清除率分别为60.7％和60.0％,不良反应发生率分别为2.4％和2.8％,两组比较差异均无显著性(P>0.05)。结论 帕尼培南/倍他米隆是治疗老年严重院内感染的一种安全。
Objective To evaluate the efficacy and safety of panipenem and betamipron in the treatment of serious in-hospital infection in elderly patients. Methods A randomized controlled study, to compare panipenem and betamipron vs imipenem and cilastatin in the treatment of 78 patients with bacterial infection of lower respiratory tract and urinary tract, was conducted to observe the clinical efficacy, bacterial eradication rates and the adverse reaction rates. Results The total clinical effective rates of panipenemand betamipron and imipenemand cilastatin were 76.2% and 69.4%, the bacterial eradication rates were 60. 7% and 60.0%, and the adverse reaction rates were 2. 4% and 2.8%, respectively. There was no significant statistical difference between the two groups (P>0. 05). Conclusions Panipenem and betamipron are effective and safe drugs in the treatment of serious in-hospital infection in elderly patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2003年第8期494-496,共3页
Chinese Journal of Geriatrics
