摘要
目的 :探讨原发性高血压 (EH)患者血浆血管紧张素Ⅱ (AngⅡ )、血清一氧化氮 (NO)含量变化及其与血压昼夜节律的相关性。方法 :EH组 5 0例 ,对照组 38例 ,以特异性放射免疫分析法测定血浆AngⅡ水平 ,用硝酸还原酶法经比色法测定血清NO水平 ,采用无创性携带式动态血压监测仪监测动态血压 ,超声心动图测定左室结构。将EH患者按动态血压监测结果分为杓型和非杓型者。比较两者的血压变化规律。结果 :①EH患者血浆AngⅡ含量明显高于对照组 (P <0 .0 1) ,NO含量明显低于对照组 (P <0 .0 1) ,且与病情严重程度相平行。②EH患者血浆AngⅡ与NO负相关 (r =- 0 .4 999,P <0 .0 1)。③非杓型者夜间收缩压均值、夜间舒张压均值增高 ,AngⅡ明显增加 ,NO明显降低 ,左室重量明显增加 ;夜间血压下降与AngⅡ负相关 (r =- 0 4 2 1,P <0 .0 5 ) ,与NO正相关 (r =0 .30 5 ,P <0 .0 5 )。结论 :AngⅡ、NO分泌失衡共同参与EH的发生、发展以及血压昼夜节律的调节。
Objective:To evaluate the changes of plasma angiotensin Ⅱ(Ang Ⅱ) and serum nitric oxide (NO) and their association with circadian rhythm of blood pressure in essential hypertension(EH).Methods:50 EH patients and 38 normotensive controls(NC) were underwent 24 hour noninvasive ambulatory blood pressure monitoring(ABPM) and examined Ang Ⅱ by radioimmunoassay (RIA) and NO by colorimeteric. Meanwhile left ventricular structure was assessed by echocardiography.Results:①The plasma Ang Ⅱ level in EH patients was higher and serum NO level was lower than those in NC(all P< 0.01 ). The change was related to the severity of disease. ②In EH groups , plasma Ang Ⅱ has negative correlation with serum NO(r=- 0.4999 ,P< 0.01 ). ③According to results of the monitoring, 50 EH patients were divided into dipper hypertension and non dipper hypertension. In non dippers, night systolic blood pressure and night diastolic blood pressure were higher than those in dippers; Moreover, Ang Ⅱ and left ventricular mass were significantly improved, and NO was markedly reduced. There was a strong negative correlation between nocturnal blood pressure fall and Ang Ⅱ(r=- 0.421 ,P< 0.05 ), while a correlation with NO(r= 0.305 ,P< 0.05 ).Conclusion:The imbalance between the Ang Ⅱ and NO may be the important cause of the hypertension and has effects on circadian rhythm of blood pressure in EH.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2003年第8期458-460,共3页
Journal of Clinical Cardiology
