摘要
用明胶 /海藻酸钠聚合物交联互穿网络作为基材 ,以戊二醛和氯化钙溶液为交联剂 ,对质子泵抑制剂药物奥美拉唑进行包覆 ,制备pH敏感型微胶囊药物制剂。测定了不同交联时间及pH值环境下的释放规律 ,研究结果表明 ,此制剂具有在酸性环境中持续释放 ,且释放百分率较小 ,而在碱性环境中为突释型制剂。此包覆体系适用于在酸性环境 (如胃 )中需要保护药效 ,防止药物失活 ;在碱性环境 (如小肠 )中发挥药效的药物制剂。
A novel pH responsive microcapsule of gelatin/sodium alginate hybrid polymer network (HPN) was prepared via the crosslinking method. Omeprazole release from the microcapsules was studied. It is found that the drug delivers much more in alkali medium than in the acidic medium for both the delivery rate and the percentage of cumulative release.
出处
《北京化工大学学报（自然科学版）》
CAS
CSCD
2003年第5期75-78,共4页
Journal of Beijing University of Chemical Technology(Natural Science Edition)
