摘要
目的 :观察大剂量静脉滴注免疫球蛋白 (HD IVIG)治疗重型格林 巴利综合征 (GBS)的疗效。方法 :选择确诊为重型GBS的病例 13例 ,于首次发病后 2周内给予HD IVIG治疗 ,剂量为 0 .4 g·kg-1·d-1,连续 5天为一疗程。治疗前后采用神经功能缺损评分法进行疗效评价。结果 :13例GBS患者治疗前后神经功能缺损评分分别为 4 .2 3± 0 .4 4与 2 .5 4± 1.4 5 ,治疗后比治疗前降低 1.6 9± 1.18,差异有显著性 (P <0 .0 1) ,同时治疗前后有很高的相关性 (P <0 .0 1)。结论 :HD IVIG治疗重型GBS疗效出现早 ,人工辅助通气时间短 。
Objective:To observe the therapeutic effect of high dose intravenous immunoglobulin(HD IVIG) on patients with severe Guillain Barre syndrome(GBS).Methods:Thirteen patients with severe GBS were selected and given HD IVIG within two weeks after the onset of neuropathic symptoms,and the dosage of IVIG was 400 mg/kg body weight per day for 5 consecutive days.The disability grade scale was adopted to evaluate the therapeutic effect before and after HD IVIG.Results:The disability grades of the patients before and after treatment of HD IVIG were 4.23±0.44 and 2.54±1.45,respectively.The grades after treatment were 1.69±1.18 lower than the grades before treatment.There was a high relativity before and after HD IVIG( P <0.01).Conclusions:HD IVIG may be the first therapeutic method for severe GBS,as it has the advantages of early occurence of the therapeutic effect and short duration of assisted ventilation.
出处
《蚌埠医学院学报》
CAS
2003年第5期402-404,共3页
Journal of Bengbu Medical College
