摘要
目的 了解血液透析患者庚型肝炎病毒 (HGV)感染情况 ,探讨其危险因素。方法 采用酶联免疫法(EL ISA)和逆转录 -套式 PCR法分别检测 4 4例血透患者的抗 - HGV抗体和 HGV RNA。结果 血透患者 HGV感染率为 13.6 % ,HGV阳性组与阴性组相比输血次数较多、透析时间较长 ,但差异无显著性 ;而单独 HGV阳性组与全阴性组相比透析时间明显延长 ,HGV感染与年龄、HBV感染、HCV感染及肝功能损害无显著相关。结论血透患者 HGV感染率明显高于普通人群 ,严格消毒措施、预防交叉感染、减少输血、血源中 HGV筛查 ,对减少透析中庚型肝炎病毒感染至关重要。
OBJECTIVE To evaluate the prevalence of and risk factors for hepatitis G virus (HGV) infection in maintenance hemodialysis (HD) patients. METHODS Serum anti HGV and HGV RNA were detected in 44 HD patients by enzyme linked immunosorbent assay (ELISA) and nested reverse transcription polymerase chain reaction (RT-PCR), respectively. RESULTS Of 44 HD patients, 4 patients (9.1%) were anti HGV positive, 3 patients (6.8%) were HGV RNA positive. Of them, only 1 patient (2.3%) was positive for both markers. The total prevalence of HGV infection is 13.6% (6 of 44 patients were positive for anti HGV and/or HGV RNA). Patients with HGV had more times of blood transfusions and longer duration of dialysis, but had no significant difference to patients without HGV. Duration of dialysis in patients with isolated HGV and negative for both HBV and HCV was significantly longer than those who were all negative for HGV, HBV and HCV. HGV infection was not associated with age, HBV infection, HCV infection, and alanine aminotransferase (ALT) level. CONCLUSIONS The prevalence of HGV infection in HD patients was significantly higher than that in general population. It is essential to perform strict sterilization and standard universal precautions, decrease transfusion, and screen for HGV in blood donors to reduce the transmission of HGV in hemodialysis units.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第9期808-810,共3页
Chinese Journal of Nosocomiology
