摘要
目的 探讨高脂血症与载脂蛋白的关系。方法 对杭州市 6 6 9名高脂血症患者和 2 6 2名健康人 ,用全自动生化分析仪测定TC、TG、HDL -C、LDL -C、ApoAⅠ、AⅡ、B、CⅡ、CⅢ、E。结果 与健康对照组比较 (1)高胆固醇血症组 ,HDL -C、LDL -C明显升高 (P <0 0 1) ,各类载脂蛋白均升高 ,尤以ApoAⅠ升高最明显。 (2 )高甘油三酯血症组 ,HDL-C低于正常对照组 (P <0 0 1) ,LDL -C无显著性差异 (P >0 0 5 ) ,ApoAⅠ降低 (P <0 0 1) ,ApoB、ApoCⅡ、ApoCⅢ、ApoE均有明显升高 (P <0 0 1)。 (3)混合型高脂血症组 ,LDL -C升高 (P <0 0 1) ,ApoAⅡ、ApoB、ApoCⅡ、ApoCⅢ、ApoE升高最明显 (P <0 0 1)。结论 高脂血症ApoAⅡ、B、CⅡ、CⅢ、E水平均升高 ;高胆固醇血症ApoAⅠ、B和HDL -C、LDL -C可同时升高 ;ApoCⅢ是高甘油三酯的重要影响因素 ;混合型高脂血症高甘油三酯伴LDL -C/HDL -C比值升高 。
Objective To explore the relationship between hyperlipidemia and serum apolipoprotein levels.Method Serum cholesterol(TC),triglyceride(TG),serum levels of high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) and levels of apolipoprotein AⅠ?AⅡ?B?CⅡ?CⅢ?E were detected in 669 patients with hyperlipidemia and 262 age-matched normolipidemia control subjects (control group).669 patients with hyperlipidemia were further divided into 3 subgroups (hypercholesterolemia group,hypertriglyceridemia group and mixed group),according to serum TC,TG levels.Results (1)The HDL-C and LDL-C in hypercholesterolemia group were significantly higher than those in control group (P<0 01).The serum levels of all kinds of apolipoprotein,especially ApoAⅠ,were also higher than those in control group.(2)The serum levels of HDL-C and ApoAⅠ in hypertriglyceridemia group were lower than those in control group (P<0 01).There was no significant difference of LDL-C between hypertriglyceridemia group and control group (P>0 05).The serum levels of ApoB?ApoCⅡ?ApoCⅢ and ApoE were significantly higher than those in control group (P<0 01).(3)The serum levels of LDL-C?ApoAⅡ?ApoB?ApoCⅡ?ApoCⅢ?ApoE were significantly higher in mixed type group (hypertriglyceridemia and hypercholesterolemia) than those in control group (P<0 01).Conclusion The serum levels of ApoAⅡ?ApoB?ApoCⅡ?ApoCⅢ?ApoE increased with hyperlipidemia and ApoAⅠ?ApoB?HDL-C?LDL-C increased with hypercholesterolemia.ApoCⅢ played an important role in hypertriglyceridemia.Hypertriglyceridemia and hypercholesterolemia combined with the raise of the ratio of LDL-C/HDL-C is the higher risk factor of coronary heart disease (CHD).
出处
《心脑血管病防治》
2003年第4期21-24,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
