期刊文献+

二价金属离子对磷脂聚集体的影响 被引量:3

Influence of Divalent Metal Ions on the Aggregation Properties of EYPC
下载PDF
导出
摘要 通过浊度分析和激光光散射光谱研究了二价金属离子(Ca2+、Cu2+和Mn2+)对蛋黄卵磷脂(EYPC)聚集态的影响.结果表明,自由的二价金属离子对EYPC囊泡有破坏作用,并使EYPC囊泡发生相转变,形成胶束;而与牛磺胆酸钠(TC)结合的二价金属离子使EYPC囊泡半径减小,但不破坏EYPC囊泡. It is well known that phosphatidylcholine (PC) vesicles are predominant carriers of cholesterol in human bile. Although the interaction of bile salts with PC has been extensively studied, relatively little attention has been given to effects of divalent metal ions on the aggregation properties of PC. We used both light scattering and UV spectroscopies to follow the effects of divalent metal ions on EYPC (egg yellow PC) vesicles. We conclude that when divalent metal ions existed, the mixed vesicles formed by PC and TC (sodium taurocholate) with the ratio of 1:3 were more stable. Free divalent metal ions act to precipitate unilamellar PC vesicles whereas, in combination with sodium taurocholate, these ions act to decrease the size of PC vesicles and induce a phase transition from PC vesicles to mixed micelles. It is a possible reason for gallstones formation when extra free divalent metal ions exist in human bile.
出处 《物理化学学报》 SCIE CAS CSCD 北大核心 2003年第8期747-750,共4页 Acta Physico-Chimica Sinica
基金 国家自然科学基金(20171004 20023005) "箘政"基金资助项目~~
关键词 二价金属离子 磷脂聚集体 蛋黄卵磷脂 牛磺胆酸钠 聚集态 胆固醇结石 浊度 激光光散射分析 胆汁 phosphatidylcholine divalent metal ions sodium taurocholate aggregation properties
  • 引文网络
  • 相关文献

参考文献10

  • 1刘之俊 吴瑾光 赵纬 吴佩强 Soloway R D 徐光宪.北京大学学报(自然科学版)(Beijing Daxue Xuebao),1994,30(6):641-641. 被引量:1
  • 2Catharina, P. N. ; Peter, M. F. ; Gerard, P. B. ; Henk, A. V. ; Jan,M. ; Karel, J. E. Biochimica et Biophysica Acta, 2002, 1583:213. 被引量:1
  • 3Tomoki, T. ; Yukihiro, T. ; Shah, M. M. ; Yuko, Y. ; Masahito,Y. Biochimica et Biophysica Acta, 2002,1564:173. 被引量:1
  • 4Feroci, G. ; Fini, A. ; Fazio, G. ; Roda, A. ; Zuman, P.Microchemical Journal, 1997, 55(3): 382. 被引量:1
  • 5Fini, A. ; Feroci, G. ; Fazio, G. ; Zuman, P. Journal of Inorganic Biochemistry, 1997, 68(4): 251. 被引量:1
  • 6Feroci, G. ; Fini, A. ; Fazio, G. ; Zuman, P. Analytical Chemistry,1995, 67(22): 4077. 被引量:1
  • 7Sun, Y. ; Yang, Z. L. ; Zhang, L. ; Hu, T. D. ; Soloway, R. D.,Weng, S. F. ; Wu, J, G. Spectrochimica Acta Part A, 2002, 58:1489. 被引量:1
  • 8Elizabeth, M. ; Stephen, B. ; Gabriel, A. E.J. Am. Chem. Soc.,1986, 108(22): 7082. 被引量:1
  • 9Moore, E. Hepatology, 1984, 4: 228S. 被引量:1
  • 10Gilat, T. ; Somjen, G. J. BBA-Rev. Biomembranes, 1996, 1286(2): 95. 被引量:1

同被引文献118

引证文献3

二级引证文献3

;
使用帮助 返回顶部