摘要
通过浊度分析和激光光散射光谱研究了二价金属离子(Ca2+、Cu2+和Mn2+)对蛋黄卵磷脂(EYPC)聚集态的影响.结果表明,自由的二价金属离子对EYPC囊泡有破坏作用,并使EYPC囊泡发生相转变,形成胶束;而与牛磺胆酸钠(TC)结合的二价金属离子使EYPC囊泡半径减小,但不破坏EYPC囊泡.
It is well known that phosphatidylcholine (PC) vesicles are predominant carriers of cholesterol in human bile. Although the interaction of bile salts with PC has been extensively studied, relatively little attention has been given to effects of divalent metal ions on the aggregation properties of PC. We used both light scattering and UV spectroscopies to follow the effects of divalent metal ions on EYPC (egg yellow PC) vesicles. We conclude that when divalent metal ions existed, the mixed vesicles formed by PC and TC (sodium taurocholate) with the ratio of 1:3 were more stable. Free divalent metal ions act to precipitate unilamellar PC vesicles whereas, in combination with sodium taurocholate, these ions act to decrease the size of PC vesicles and induce a phase transition from PC vesicles to mixed micelles. It is a possible reason for gallstones formation when extra free divalent metal ions exist in human bile.
出处
《物理化学学报》
SCIE
CAS
CSCD
北大核心
2003年第8期747-750,共4页
Acta Physico-Chimica Sinica
基金
国家自然科学基金(20171004
20023005)
"箘政"基金资助项目~~